Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure
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Date
2021
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Abstract
Chronic heart failure (CHF) is a global health problem. Increased sympathetic outfow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activation of the renin-angiotensin system (RAS) play a key role in CHF pathophysiology. Interestingly, potassium (K+) supplemented diets showed promising results in normalizing RAS axis and autonomic dysfunction in
vascular diseases, lowering cardiovascular risk. Whether subtle increases in dietary K+ consumption may exert similar efects in CHF has not been previously tested. Accordingly, we aimed to evaluate the efects of dietary K+ supplementation on cardiorespiratory alterations in rats with CHF.
Methods: Adult male Sprague–Dawley rats underwent volume overload to induce non-ischemic CHF. Animals were randomly allocated to normal chow diet (CHF group) or supplemented K+ diet (CHF+K+ group) for 6 weeks. Cardiac arrhythmogenesis, sympathetic outfow, barorefex sensitivity, breathing disorders, chemorefex function, respiratory–cardiovascular coupling and cardiac function were evaluated.
Results: Compared to normal chow diet, K+ supplemented diet in CHF signifcantly reduced arrhythmia incidence (67.8±15.1 vs. 31.0±3.7 events/hour, CHF vs. CHF+K+), decreased cardiac sympathetic tone (ΔHR to propranolol: −97.4±9.4 vs. −60.8±8.3 bpm, CHF vs. CHF+K+), restored barorefex function and attenuated irregular breathing patterns. Additionally, supplementation of the diet with K+ restores normal central respiratory chemorefex drive and abrogates pathological cardio-respiratory coupling in CHF rats being the outcome an improved cardiac function.
Conclusion: Our fndings support that dietary K+ supplementation in non-ischemic CHF alleviate cardiorespiratory dysfunction.
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Keywords
Heart failure, Potassium supplemented diet, Autonomic imbalance, Breathing disorders, Chemorefex function
Citation
Biological Research. 2021 Dec 24;54(1):43