Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure

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dc.contributor.authorSchwarz Flores, Karla Gabriele
dc.contributor.authorPereyra Florián, Katherin Vanessa
dc.contributor.authorToledo, Camilo
dc.contributor.authorAndrade Andrade, David Cristóbal
dc.contributor.authorDíaz, Hugo S.
dc.contributor.authorDíaz Jara, Esteban
dc.contributor.authorOrtiz Cisternas, Fernando Andrés
dc.contributor.authorInestrosa Cantín, Nibaldo
dc.contributor.authorVio Lagos, Carlos P.
dc.contributor.authorRío Troncoso, Rodrigo Andre del
dc.date.accessioned2021-12-30T20:05:41Z
dc.date.available2021-12-30T20:05:41Z
dc.date.issued2021
dc.date.updated2021-12-26T01:02:18Z
dc.description.abstractChronic heart failure (CHF) is a global health problem. Increased sympathetic outfow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activation of the renin-angiotensin system (RAS) play a key role in CHF pathophysiology. Interestingly, potassium (K+) supplemented diets showed promising results in normalizing RAS axis and autonomic dysfunction in vascular diseases, lowering cardiovascular risk. Whether subtle increases in dietary K+ consumption may exert similar efects in CHF has not been previously tested. Accordingly, we aimed to evaluate the efects of dietary K+ supplementation on cardiorespiratory alterations in rats with CHF. Methods: Adult male Sprague–Dawley rats underwent volume overload to induce non-ischemic CHF. Animals were randomly allocated to normal chow diet (CHF group) or supplemented K+ diet (CHF+K+ group) for 6 weeks. Cardiac arrhythmogenesis, sympathetic outfow, barorefex sensitivity, breathing disorders, chemorefex function, respiratory–cardiovascular coupling and cardiac function were evaluated. Results: Compared to normal chow diet, K+ supplemented diet in CHF signifcantly reduced arrhythmia incidence (67.8±15.1 vs. 31.0±3.7 events/hour, CHF vs. CHF+K+), decreased cardiac sympathetic tone (ΔHR to propranolol: −97.4±9.4 vs. −60.8±8.3 bpm, CHF vs. CHF+K+), restored barorefex function and attenuated irregular breathing patterns. Additionally, supplementation of the diet with K+ restores normal central respiratory chemorefex drive and abrogates pathological cardio-respiratory coupling in CHF rats being the outcome an improved cardiac function. Conclusion: Our fndings support that dietary K+ supplementation in non-ischemic CHF alleviate cardiorespiratory dysfunction.
dc.format.extent14 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationBiological Research. 2021 Dec 24;54(1):43
dc.identifier.doi10.1186/s40659-021-00365-z
dc.identifier.urihttps://doi.org/10.1186/s40659-021-00365-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/63100
dc.information.autorucFacultad de ciencias biológicas ; Schwarz Flores, Karla Gabriele ; 0000-0002-2503-3402 ; 1101566
dc.information.autorucFacultad de ciencias biológicas ; Pereyra Florián, Katherin Vanessa ; 1027823
dc.information.autorucFacultad de ciencias biológicas ; Andrade Andrade, David Cristóbal ; 0000-0003-2006-1444 ; 237258
dc.information.autorucFacultad de ciencias biológicas ; Díaz Jara, Esteban ; S/I ; 1092046
dc.information.autorucFacultad de ciencias biológicas ; Ortiz Cisternas, Fernando Andrés ; S/I ; 166432
dc.information.autorucFacultad de ciencias biológicas ; Inestrosa Cantín, Nibaldo ; 0000-0003-3118-9726 ; 99331
dc.information.autorucFacultad de ciencias biológicas ; Vio Lagos, Carlos P. ; 0000-0003-1850-5958 ; 99575
dc.information.autorucFacultad de ciencias biológicas ; Río Troncoso, Rodrigo Andre del ; 0000-0002-2562-806X ; 126608
dc.issue.numeroNo. 1
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaBiological Researches_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectHeart failurees_ES
dc.subjectPotassium supplemented dietes_ES
dc.subjectAutonomic imbalancees_ES
dc.subjectBreathing disorderses_ES
dc.subjectChemorefex functiones_ES
dc.subject.ddc616
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherInsuficiencia cardíacaes_ES
dc.subject.otherPotasio - Efectos Fisiológicoses_ES
dc.subject.otherDietoterapiaes_ES
dc.titleEffects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure
dc.typeartículo
sipa.codpersvinculados1101566
sipa.codpersvinculados1027823
sipa.codpersvinculados237258
sipa.codpersvinculados1092046
sipa.codpersvinculados166432
sipa.codpersvinculados99331
sipa.codpersvinculados99575
sipa.codpersvinculados126608
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