A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
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Date
2020
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Volume Title
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Abstract
Abstract
Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing.
In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
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Keywords
Mechanical ventilation, SARS-CoV2, COVID-19, P-SILI, Lung strain, Work of breathing
Citation
Critical Care. 2020 Aug 10;24(1):494