A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

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dc.contributor.authorCruces, Pablo
dc.contributor.authorRetamal Montes, Jaime
dc.contributor.authorHurtado Sepúlveda, Daniel
dc.contributor.authorErranz, Benjamín
dc.contributor.authorIturrieta, Pablo
dc.contributor.authorGonzález, Carlos
dc.contributor.authorDíaz, Franco
dc.date.accessioned2020-08-18T14:55:16Z
dc.date.available2020-08-18T14:55:16Z
dc.date.issued2020
dc.date.updated2020-08-16T00:04:08Z
dc.description.abstractAbstract Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
dc.format.extent10 páginas
dc.identifier.citationCritical Care. 2020 Aug 10;24(1):494
dc.identifier.doi10.1186/s13054-020-03197-7
dc.identifier.urihttps://doi.org/10.1186/s13054-020-03197-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/38952
dc.issue.numeroNo. 494
dc.language.isoen
dc.pagina.final10
dc.pagina.inicio1
dc.revistaCritical Carees_ES
dc.rights.holderThe Author(s)
dc.subjectMechanical ventilationes_ES
dc.subjectSARS-CoV2es_ES
dc.subjectCOVID-19es_ES
dc.subjectP-SILIes_ES
dc.subjectLung straines_ES
dc.subjectWork of breathinges_ES
dc.subject.ddc616.24
dc.subject.deweyMedicina y saludes_ES
dc.titleA physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infectiones_ES
dc.typeartículo
dc.volumenVol. 24
sipa.codpersvinculados175147
sipa.codpersvinculados3569
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