Browsing by Author "González, Carlos"
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- ItemA physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection(2020) Cruces, Pablo; Retamal Montes, Jaime; Hurtado Sepúlveda, Daniel; Erranz, Benjamín; Iturrieta, Pablo; González, Carlos; Díaz, FrancoAbstract Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
- ItemRenal decapsulation prevents intrinsic renal compartment syndrome in ischemia-reperfusion - Induced acute kidney injury : a physiologic approach(2018) Cruces, Pablo; Lillo, Pablo; Salas, Camila; Salomon, Tatiana; Lillo, Felipe; González, Carlos; Pacheco, Alejandro; Hurtado Sepúlveda, Daniel
- ItemTetrahydrohyperforin inhibits the proteolytic processing of amyloid precursor protein and enhances its degradation by Atg5-dependent autophagy(2015) Cavieres, Viviana A.; González, Alexis; Muñoz, Vanessa C.; Yefi Rubio, Claudia Pamela; Bustamante, Hianara A.; Barraza, Rafael R.; Tapia Rojas, Cheril Cecilia; Otth, Carola; Barrera, María José; Inestrosa Cantín, Nibaldo; Mardones, Gonzalo A.; González, Carlos; Burgos, Patricia V.