Identification of The Distinctive Type i/XhoI plus Strain of Epstein-Barr Virus in Gastric Carcinoma in Peru
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
INT INST ANTICANCER RESEARCH
Abstract
Aim: To clarify the reason for the low frequency of Epstein-Barr virus-associated gastric carcinoma (EBVaGC) in Peru, despite the high frequency reported in neighboring countries, the distribution of the distinctive EBV (type i/XhoI+) strain in EBVaGC and a healthy population was examined. Materials and Methods: EBV polymorphisms in BamHI W1/I1 and XhoI restriction site of the latent membrane protein 1 gene (LMP1) were examined among 11 EBVaGCs and 172 healthy controls from Peru, and these frequencies were compared with those in a previous study of Chile and Colombia (n=303). Results: The frequency of the distinctive EBV strain in EBVaGCs (55%) was significantly higher than that in controls (7%). Furthermore, the frequency of this EBV type in Peruvian controls was significantly lower than that in controls from Chile and Colombia (27%, p<0.001). Conclusion: The low frequency of the distinctive EBV strain among the Peruvian population might be a reason for the lower incidence of EBVaGC in Peru, as compared with neighboring countries.
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Keywords
EBV polymorphism, BamHI W1/I1, XhoI restriction site, EBV-associated gastric cancer, Latin America, GROWTH-FACTOR RECEPTOR, MEMBRANE-PROTEIN 2A, ENCODED SMALL RNA, NASOPHARYNGEAL CARCINOMA, EPITHELIAL-CELLS, EXPRESSION, GENE, EBV, SOUTHERN, DNA