Identification of The Distinctive Type i/XhoI plus Strain of Epstein-Barr Virus in Gastric Carcinoma in Peru

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dc.contributor.authorOrdonez, Paula
dc.contributor.authorKoriyama, Chihaya
dc.contributor.authorDing, Shan
dc.contributor.authorYoshiwara, Elena
dc.contributor.authorCorvalan, Alejandro H.
dc.contributor.authorTakano, Juan
dc.contributor.authorChirinos, Jesus L.
dc.contributor.authorWatanabe, Jose
dc.contributor.authorMiyagui, Juan
dc.contributor.authorHidalgo, Heriberto
dc.contributor.authorChacon, Pedro
dc.contributor.authorLinares, Victor
dc.contributor.authorEizuru, Yoshito
dc.contributor.authorAkiba, Suminori
dc.date.accessioned2024-01-10T13:13:37Z
dc.date.available2024-01-10T13:13:37Z
dc.date.issued2011
dc.description.abstractAim: To clarify the reason for the low frequency of Epstein-Barr virus-associated gastric carcinoma (EBVaGC) in Peru, despite the high frequency reported in neighboring countries, the distribution of the distinctive EBV (type i/XhoI+) strain in EBVaGC and a healthy population was examined. Materials and Methods: EBV polymorphisms in BamHI W1/I1 and XhoI restriction site of the latent membrane protein 1 gene (LMP1) were examined among 11 EBVaGCs and 172 healthy controls from Peru, and these frequencies were compared with those in a previous study of Chile and Colombia (n=303). Results: The frequency of the distinctive EBV strain in EBVaGCs (55%) was significantly higher than that in controls (7%). Furthermore, the frequency of this EBV type in Peruvian controls was significantly lower than that in controls from Chile and Colombia (27%, p<0.001). Conclusion: The low frequency of the distinctive EBV strain among the Peruvian population might be a reason for the lower incidence of EBVaGC in Peru, as compared with neighboring countries.
dc.description.funderMinistry of Education, Science, Sports and Culture of Japan
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.issn0250-7005
dc.identifier.pubmedidMEDLINE:21965785
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78322
dc.identifier.wosidWOS:000295667700070
dc.information.autorucMedicina;Corvalan A;S/I;63885
dc.issue.numero10
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final3613
dc.pagina.inicio3607
dc.publisherINT INST ANTICANCER RESEARCH
dc.revistaANTICANCER RESEARCH
dc.rightsregistro bibliográfico
dc.subjectEBV polymorphism
dc.subjectBamHI W1/I1
dc.subjectXhoI restriction site
dc.subjectEBV-associated gastric cancer
dc.subjectLatin America
dc.subjectGROWTH-FACTOR RECEPTOR
dc.subjectMEMBRANE-PROTEIN 2A
dc.subjectENCODED SMALL RNA
dc.subjectNASOPHARYNGEAL CARCINOMA
dc.subjectEPITHELIAL-CELLS
dc.subjectEXPRESSION
dc.subjectGENE
dc.subjectEBV
dc.subjectSOUTHERN
dc.subjectDNA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIdentification of The Distinctive Type i/XhoI plus Strain of Epstein-Barr Virus in Gastric Carcinoma in Peru
dc.typeartículo
dc.volumen31
sipa.codpersvinculados63885
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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