C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy

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dc.contributor.authorOlmos, Pablo
dc.contributor.authorBastias, Maria Juliana
dc.contributor.authorVollrath, Valeska
dc.contributor.authorToro, Luis
dc.contributor.authorTrincado, Arturo
dc.contributor.authorSalinas, Pablo
dc.contributor.authorClaro, Juan Carlos
dc.contributor.authorLopez, Jose Manuel
dc.contributor.authorAcosta, Ana Maria
dc.contributor.authorMiquel, Juan Francisco
dc.contributor.authorCastro, Juan
dc.date.accessioned2024-01-10T13:11:32Z
dc.date.available2024-01-10T13:11:32Z
dc.date.issued2006
dc.description.abstractPurpose: To study the C(-106)T polymorphism in the promoter of the aldose reductase (ALR2) gene: (a) its local prevalence and (b) its modulation of the susceptibility for developing retinopathy.
dc.description.abstractMethods: DNAs of 96 control subjects and 53 long-standing (duration 17.9 +/- 5.4 years) type-2 diabetic patients were analyzed by PCR-RFLP with BfaI enzyme. Retinopathy was graded with 2-eye, 7-field fundus color photography. The IMF-HbA1c was the arithmetic mean of all HbA1c's of each patient.
dc.description.abstractResults: The genotypes in the controls were CC = 57 (59.4%), CT = 32 (33.3%) and TT = 7 (7.3%), with Hardy-Weinberg chi(2) = 0.793 (p > 0.50). Among 53 diabetics, CC = 24 (45.3%), CT = 26 (49.0%) and TT = 3 (5.7%). The correlation between IMF-HbA1c and retinopathy progression rate was significant on CC (r = 0.6102, p = 0.0072) but not in CT + TT genotypes (r = 0.26, p = 0.1811).
dc.description.abstractConclusions: In Chilean adults, the frequency of the C(-106)T polymorphism of the ALR2 gene was similar to that reported by others. Type-2 diabetics with the CC genotype were more susceptible for developing retinopathy as a result of chronic hyperglycemia than those with the CT or TT genotype. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
dc.fechaingreso.objetodigital2024-04-09
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.diabres.2006.03.019
dc.identifier.issn0168-8227
dc.identifier.pubmedidMEDLINE:16701918
dc.identifier.urihttps://doi.org/10.1016/j.diabres.2006.03.019
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78058
dc.identifier.wosidWOS:000241649700010
dc.information.autorucMedicina;Miquel J;S/I;72216
dc.information.autorucMedicina;Olmos P;S/I;98949
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final182
dc.pagina.inicio175
dc.publisherELSEVIER IRELAND LTD
dc.revistaDIABETES RESEARCH AND CLINICAL PRACTICE
dc.rightsacceso restringido
dc.subjectaldose reductase
dc.subjectpolymorphism
dc.subjectdiabetes
dc.subjectretinopathy
dc.subjectMICROVASCULAR COMPLICATIONS
dc.subjectJAPANESE PATIENTS
dc.subjectMELLITUS
dc.subjectSUSCEPTIBILITY
dc.subjectNEPHROPATHY
dc.subjectREGION
dc.subjectNIDDM
dc.subjectRISK
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleC(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy
dc.typeartículo
dc.volumen74
sipa.codpersvinculados72216
sipa.codpersvinculados98949
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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