Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones

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dc.contributor.authorValderrama, Jaime A.
dc.contributor.authorLeiva, Hilda
dc.contributor.authorRodriguez, Jaime A.
dc.contributor.authorTheoduloz, Cristina
dc.contributor.authorSchmeda Hirshmann, Guillermo
dc.date.accessioned2024-01-10T13:43:40Z
dc.date.available2024-01-10T13:43:40Z
dc.date.issued2008
dc.description.abstractA series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human. broblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC50 1.3-89.5 mu M, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety. (C) 2008 Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital21-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bmc.2008.02.018
dc.identifier.eissn1464-3391
dc.identifier.issn0968-0896
dc.identifier.pubmedidMEDLINE:18299197
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2008.02.018
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78716
dc.identifier.wosidWOS:000255245900022
dc.information.autorucQuímica;Leiva H;S/I;4408
dc.information.autorucQuímica;Valderrama J;S/I;98772
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final3693
dc.pagina.inicio3687
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaBIOORGANIC & MEDICINAL CHEMISTRY
dc.rightsacceso restringido
dc.subject1,4-naphthoquinones
dc.subjectpodands
dc.subjectcoronands
dc.subjectnucleophilic substitution
dc.subjectcytotoxicity
dc.subjectDNA TOPOISOMERASE-I
dc.subjectANTITUMOR-ACTIVITY
dc.subjectNAPHTHAZARIN DERIVATIVES
dc.subjectANTIPROLIFERATIVE ACTIVITY
dc.subjectLEISHMANICIDAL ACTIVITY
dc.subjectBIOLOGICAL-ACTIVITY
dc.subjectANTICANCER AGENTS
dc.subjectP-BENZOQUINONE
dc.subjectHYDROQUINONES
dc.subjectACCESS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStudies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones
dc.typeartículo
dc.volumen16
sipa.codpersvinculados4408
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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