Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones
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Date
2008
Journal Title
Journal ISSN
Volume Title
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Abstract
A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human. broblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC50 1.3-89.5 mu M, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety. (C) 2008 Elsevier Ltd. All rights reserved.
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Keywords
1,4-naphthoquinones, podands, coronands, nucleophilic substitution, cytotoxicity, DNA TOPOISOMERASE-I, ANTITUMOR-ACTIVITY, NAPHTHAZARIN DERIVATIVES, ANTIPROLIFERATIVE ACTIVITY, LEISHMANICIDAL ACTIVITY, BIOLOGICAL-ACTIVITY, ANTICANCER AGENTS, P-BENZOQUINONE, HYDROQUINONES, ACCESS