Microwave-assisted synthesis and regioisomeric structural elucidation of novel benzimidazo[1,2d][1,4]benzodiazepinone derivatives
Loading...
Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
ARKAT USA INC
Abstract
The synthesis of 5H-benzimidazo [1,2-d] [1,4] benzodiazepin -6(7H)-ones 3a-e from readily available 2-(2-aminophenyl)-1H-benzo[d]imidazole derivatives 2a-e and 2-bromoacetyl bromide under microwave conditions is described. Unambiguous structural elucidation of the obtained regioisomers was finally established by means of 2D-NOESY experiment.
Description
Keywords
Heterocycles, benzimidazoles, benzodiazepines, microwaves, BIOLOGICAL-ACTIVITY, ANTITUMOR-ACTIVITY, ANALOGS