Genotipos de virus papiloma humano (VPH) en pacientes con cáncer cérvico-uterino en un hospital público y una clínica privada de Santiago, Chile

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dc.catalogadorpau
dc.contributor.authorValdivia Leiva, Isabel Margarita
dc.contributor.authorAguayo González, Francisco Renan
dc.contributor.authorPruyas A., Martha
dc.contributor.authorSnijders, Peter J. F.
dc.contributor.authorCorvalán Rodríguez, Alejandro
dc.contributor.authorFerreccio Readi, Fresia Catterina
dc.date.accessioned2024-06-08T16:01:21Z
dc.date.available2024-06-08T16:01:21Z
dc.date.issued2010
dc.description.abstractWe compared HPV genotypes among squamous cervical cancer samples from a public hospital (n = 55) and a private clinic (n = 35 cases) of Santiago. Paraffin-embedded specimens were analyzed by PCR followed by an immunoenzimatic assay. Reverse line blotting was used for the identification of 36 HPV genotypes. We found HPV DNA in 94.4% of all cancers. Single infections: HPV16: 40.0%, (clinic 37.1%, hospital 41.8%) VPH18:7.8% (clinic 2.9%, hospital 10.9%); single+multiple infections: VPH16: 61.1% (clinic 53.1%, hospital 71.7%), VPH18: 34.4% (clinic 21.9%, hospital 45.2%). HPV16 or HPV18 occurred in 75.6% of cases, higher in the hospital than the clinic (87.3%-95% CI: 84.9-96.3 - and 57.1%-95% CI: 46.6-66 - respectively, p = 0.002). Other genotypes in single infections: HPV 26, 31, 33, 45, 58, 67; in co-infections: HPV 35,52,56,59 and 66. HPV16 but specially HPV18 were significantly more frequent in the public hospital; 75.6% of squamous cervical cancer were associated to the vaccine preventable HPV16/18.
dc.fechaingreso.objetodigital2024-06-08
dc.fuente.origenScopus
dc.identifier.issn0716-1018
dc.identifier.pubmedid20140308
dc.identifier.scopusidSCOPUS_ID:77953048138
dc.identifier.urihttp://www.scielo.cl/pdf/rci/v27n1/art01.pdf
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86640
dc.information.autorucFacultad de Ciencias Biológicas; Valdivia Leiva, Isabel Margarita; S/I; 132580
dc.information.autorucEscuela de Medicina; Aguayo González, Francisco Renan; S/I; 1005475
dc.information.autorucEscuela de Medicina; Corvalán Rodríguez, Alejandro; 0000-0001-5492-3853; 63885
dc.information.autorucEscuela de Medicina; Ferreccio Readi, Fresia Catterina; 0000-0001-6331-5534; 99684
dc.language.isoes
dc.nota.accesocontenido completo
dc.pagina.final16
dc.pagina.inicio11
dc.revistaRevista Chilena de Infectología
dc.rightsacceso abierto
dc.subjectCervical cancer
dc.subjectGenotypes
dc.subjectHuman papillomavirus (HPV)
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleGenotipos de virus papiloma humano (VPH) en pacientes con cáncer cérvico-uterino en un hospital público y una clínica privada de Santiago, Chile
dc.title.alternativeHuman papillomavirus (HPV) genotypes in cervix uterine cancer patients in a public hospital and private clinic from Santiago, Chile
dc.typeartículo
dc.volumen27
sipa.codpersvinculados132580
sipa.codpersvinculados1005475
sipa.codpersvinculados63885
sipa.codpersvinculados99684
sipa.trazabilidadScopus;2021-10-12
sipa.trazabilidadORCID;2024-06-03
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