Differences of affective and non-affective psychoses in early intervention services from Latin America

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dc.catalogadorgrr
dc.contributor.authorCerqueira, Raphael O.
dc.contributor.authorZiebold, Carolina
dc.contributor.authorCavalcante, Daniel
dc.contributor.authorOliveira, Giovany
dc.contributor.authorVasquez Nuñez, Javiera Eugenia
dc.contributor.authorUndurraga, Juan
dc.contributor.authorGonzalez-Valderrama, Alfonso
dc.contributor.authorNachar, Ruben
dc.contributor.authorLopez-Jaramillo, Carlos
dc.contributor.authorNoto, Cristiano
dc.contributor.authorCrossley Karmelic, Nicolas Andres
dc.contributor.authorGadelha, Ary
dc.date.accessioned2024-06-05T19:26:36Z
dc.date.available2024-06-05T19:26:36Z
dc.date.issued2022
dc.description.abstractBackground: Psychosis presentation can be affected by genetic and environmental factors. Differentiating be-tween affective and non-affective psychosis (A-FEP and NA-FEP, respectively) may influence treatment decisions and clinical outcomes. The objective of this paper is to examine differences between patients with A-FEP or NA-FEP in a Latin American sample.Methods: Patients from two cohorts of patients with a FEP recruited from Brazil and Chile. Subjects included were aged between 15 and 30 years, with an A-FEP or NA-FEP (schizophrenia-spectrum disorders) according to DSM-IV-TR. Sociodemographic data, duration of untreated psychosis and psychotic/mood symptoms were assessed. Generalized estimating equation models were used to assess clinical changes between baseline-follow-up ac-cording to diagnosis status.Results: A total of 265 subjects were included. Most of the subjects were male (70.9 %), mean age was 21.36 years. A-FEP and NA-FEP groups were similar in almost all sociodemographic variables, but A-FEP patients had a higher probability of being female. At baseline, the A-FEP group had more manic symptoms and a steeper reduction in manic symptoms scores during the follow-up. The NA-FEP group had more negative symptoms at baseline and a higher improvement during follow-up. All domains of The Positive and Negative Syndrome Scale improved for both groups. No difference for DUP and depression z-scores at baseline and follow-up. Limitations: The sample was recruited at tertiary hospitals, which may bias the sample towards more severe cases.Conclusions: This is the largest cohort comparing A-FEP and NA-FEP in Latin America. We found that features in FEP patients could be used to improve diagnosis and support treatment decisions.
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jad.2022.08.010
dc.identifier.eissn1573-2517
dc.identifier.issn0165-0327
dc.identifier.pubmedid35961602
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85135882714
dc.identifier.urihttp://doi.org/10.1016/j.jad.2022.08.010
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86468
dc.identifier.wosidWOS:000848172100012
dc.information.autorucInstituto de Sociología; Vasquez Nuñez, Javiera Eugenia; 0000-0003-3552-865X; 1003239
dc.information.autorucEscuela de Medicina; Crossley Karmelic, Nicolas Andres; 0000-0002-3060-656X; 11224
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final90
dc.pagina.inicio83
dc.revistaJournal of affective Disorders
dc.rightsacceso restringido
dc.subjectFirst-episode
dc.subjectPsychosis
dc.subjectSchizophrenia
dc.subjectBipolar disorder
dc.subjectDepression
dc.subject.ddc150
dc.subject.deweyPsicologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferences of affective and non-affective psychoses in early intervention services from Latin America
dc.typeartículo
dc.volumen316
sipa.codpersvinculados1003239
sipa.codpersvinculados11224
sipa.trazabilidadWOS;2022-10-11
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