Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands

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dc.catalogadorjwg
dc.contributor.authorEspinosa Bustos, Christian
dc.contributor.authorIturriaga Vásquez, Patricio
dc.contributor.authorLagos, Carlos
dc.contributor.authorMella Raipán, Jaime
dc.contributor.authorPessoa Mahana, Carlos David
dc.contributor.authorPessoa Mahana, Hernán
dc.contributor.authorRecabarren Gajardo, Gonzalo Iván
dc.contributor.authorRomero Parra, Javier Hernán
dc.date.accessioned2024-06-05T13:29:18Z
dc.date.available2024-06-05T13:29:18Z
dc.date.issued2013
dc.description.abstractA series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinitie
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-06-04
dc.fuente.origenORCID
dc.identifier.citationJaime A. Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo, Christian Espinosa-Bustos, Javier Romero-Parra, Hernán Pessoa-Mahana, Patricio Iturriaga-Vásquez, C. David Pessoa-Mahana. Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles: a new family of high affinity CB1 cannabinoid ligands. Molecules. 2013;18:3972-4001.
dc.identifier.doi10.3390/molecules18043972
dc.identifier.urihttps://doi.org/10.3390/molecules18043972
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86421
dc.identifier.wosidWOS:000318020100024
dc.information.autorucEscuela de Química; Pessoa Mahana Carlos David; S/I; 76905
dc.information.autorucEscuela de Química; Romero Parra Javier Hernan; S/I; 126302
dc.information.autorucEscuela de Química; Recabarren Gajardo Gonzalo Ivan; 0000-0002-7763-7830; 1006710
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final4001
dc.pagina.inicio3972
dc.revistaMolecules
dc.rightsacceso abierto
dc.subjectCannabinoid
dc.subjectCb1 Receptor
dc.subjectBinding
dc.subjectDocking
dc.subject3d-Qsar
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleDesign, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands
dc.typeartículo
dc.volumen18
sipa.codpersvinculados76905
sipa.codpersvinculados126302
sipa.codpersvinculados1006710
sipa.trazabilidadORCID;2024-06-03
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