Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands
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Date
2013
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Abstract
A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinitie
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Keywords
Cannabinoid, Cb1 Receptor, Binding, Docking, 3d-Qsar
Citation
Jaime A. Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo, Christian Espinosa-Bustos, Javier Romero-Parra, Hernán Pessoa-Mahana, Patricio Iturriaga-Vásquez, C. David Pessoa-Mahana. Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles: a new family of high affinity CB1 cannabinoid ligands. Molecules. 2013;18:3972-4001.