Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes

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dc.contributor.authorGalaz, Jose
dc.contributor.authorRomero, Roberto
dc.contributor.authorSlutsky, Rebecca
dc.contributor.authorXu, Yi
dc.contributor.authorMotomura, Kenichiro
dc.contributor.authorPara, Robert
dc.contributor.authorPacora, Percy
dc.contributor.authorPanaitescu, Bogdan
dc.contributor.authorHsu, Chaur Dong
dc.contributor.authorKacerovsky, Marian
dc.contributor.authorGomez Lopez, Nardhy
dc.date.accessioned2024-01-10T13:11:36Z
dc.date.available2024-01-10T13:11:36Z
dc.date.issued2020
dc.description.abstractBackground: Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morbidity. However, the cellular immune responses in amniotic fluid of women with pPROM have not been investigated.
dc.description.abstractMethods: Amniotic fluid samples were obtained from women with pPROM and a positive (n = 7) or negative (n =10) microbiological culture. Flow cytometry was performed to evaluate the phenotype and number of amniotic fluid leukocytes. The correlation between amniotic fluid immune cells and an interleukin-6 (IL-6) concentration or a white blood cell (WBC) count in amniotic fluid was calculated.
dc.description.abstractResults: Women with pPROM and a positive amniotic fluid culture had (1) a greater number of total leukocytes in amniotic fluid, including neutrophils and monocytes/macrophages and (2) an increased number of total T cells in amniotic fluid, namely CD4+ T cells and CD8+ T cells, but not B cells. The numbers of neutrophils and monocytes/macrophages were positively correlated with IL -6 concentrations and WBC counts in amniotic fluid of women with pPROM.
dc.description.abstractConclusion: Women with pPROM and a positive amniotic fluid culture exhibit a more severe cellular immune response than those with a negative culture, which is associated with well-known markers of intra-amniotic inflammation.
dc.description.funderPerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and
dc.description.funderNICHD/NIH/DHHS
dc.description.funderWayne State University Perinatal Initiative in Maternal, Perinatal and Child Health
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1515/jpm-2019-0395
dc.identifier.eissn1619-3997
dc.identifier.issn0300-5577
dc.identifier.pubmedidMEDLINE:32083453
dc.identifier.urihttps://doi.org/10.1515/jpm-2019-0395
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78070
dc.identifier.wosidWOS:000518390600005
dc.information.autorucIngeniería;Galaz Mora Jose Daniel;S/I;177842
dc.issue.numero3
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final233
dc.pagina.inicio222
dc.publisherWALTER DE GRUYTER GMBH
dc.revistaJOURNAL OF PERINATAL MEDICINE
dc.rightsregistro bibliográfico
dc.subjectacute chorioamnionitis
dc.subjectclinical chorioamnionitis
dc.subjectfetal inflammatory response
dc.subjectfunisitis
dc.subjectinnate immune cells
dc.subjectinterleukin-6
dc.subjectlabor
dc.subjectmicrobial invasion of the amniotic cavity
dc.subjectpregnancy
dc.subjectprematurity
dc.subjectpreterm labor
dc.subjectMACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA
dc.subjectACTIVATING PEPTIDE-1 INTERLEUKIN-8
dc.subjectTUMOR-NECROSIS-FACTOR
dc.subjectPREMATURE RUPTURE
dc.subjectFETAL MEMBRANES
dc.subjectINTRAAMNIOTIC INFLAMMATION
dc.subjectMICROBIAL INVASION
dc.subjectINTRAUTERINE INFECTION
dc.subjectHUMAN PARTURITION
dc.subjectGRAM STAIN
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleCellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes
dc.typeartículo
dc.volumen48
sipa.codpersvinculados177842
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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