Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones

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dc.contributor.authorVasquez, David
dc.contributor.authorRodriguez, Jaime A.
dc.contributor.authorTheoduloz, Cristina
dc.contributor.authorVerrax, Julien
dc.contributor.authorCalderon, Pedro Buc
dc.contributor.authorValderrama, Jaime A.
dc.date.accessioned2024-01-10T12:09:04Z
dc.date.available2024-01-10T12:09:04Z
dc.date.issued2009
dc.description.abstractA series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives were prepared by regioselective amination reaction of pyrimido[4,5-c] isoquinoline-7,10-quinones with arylamines in the presence of a Lewis acid catalyst. Preliminary evaluation of the members of the series against cancer cell lines and assays of activation of their cytotoxic activity on K562 cells with ascorbic acid are reported. (C) 2009 Elsevier Ltd. All rights reserved.
dc.description.funderFONDECYT
dc.description.funderCONICYTCGRI
dc.fechaingreso.objetodigital21-03-2024
dc.format.extent3 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bmcl.2009.07.041
dc.identifier.eissn1464-3405
dc.identifier.issn0960-894X
dc.identifier.pubmedidMEDLINE:19631536
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2009.07.041
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76455
dc.identifier.wosidWOS:000268863800037
dc.information.autorucQuímica;Valderrama JA;S/I;98772
dc.issue.numero17
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final5062
dc.pagina.inicio5060
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
dc.rightsacceso restringido
dc.subjectPyrimido[45-c]isoquinolinequinones
dc.subjectSubstitution reaction
dc.subjectRedox-cycling, cancer cells, cytotoxicity
dc.subject2-METHYL-1,4-NAPHTHOQUINONE VITAMIN-K3 TREATMENT
dc.subjectASCORBATE
dc.subjectAUTOSCHIZIS
dc.subjectSYNERGISM
dc.subjectCELLS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones
dc.typeartículo
dc.volumen19
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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