Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones
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Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Abstract
A series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives were prepared by regioselective amination reaction of pyrimido[4,5-c] isoquinoline-7,10-quinones with arylamines in the presence of a Lewis acid catalyst. Preliminary evaluation of the members of the series against cancer cell lines and assays of activation of their cytotoxic activity on K562 cells with ascorbic acid are reported. (C) 2009 Elsevier Ltd. All rights reserved.
Description
Keywords
Pyrimido[45-c]isoquinolinequinones, Substitution reaction, Redox-cycling, cancer cells, cytotoxicity, 2-METHYL-1,4-NAPHTHOQUINONE VITAMIN-K3 TREATMENT, ASCORBATE, AUTOSCHIZIS, SYNERGISM, CELLS