New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence

Nieto Pacheco, Pamela Andrea; Pardo Roa, Catalina; Salazar Echegarai, Francisco Javier; Tobar Durán, Hugo Eduardo; Coronado Arrázola, Irenice; Riedel, Claudia A.; Kalergis Parra, Alexis Mikes; Bueno Ramírez, Susan

New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence

Date

2016

Authors

Nieto Pacheco, Pamela Andrea

Pardo Roa, Catalina

Salazar Echegarai, Francisco Javier

Tobar Durán, Hugo Eduardo

Coronado Arrázola, Irenice

Riedel, Claudia A.

Kalergis Parra, Alexis Mikes

Bueno Ramírez, Susan

Abstract

Pathogenicity islands (PAIs) are regions of the chromosome of pathogenic bacteria that harbor virulence genes, which were probably acquired by lateral gene transfer. Several PAIs can excise from the bacterial chromosome by site-specific recombination and in this review have been denominated "excisable PAIs ". Here, the characteristic of some of the excisable PAIs from Salmonella enterica and the possible role and impact of the excision process on bacterial virulence is discussed. Understanding the role of PAI excision could provide important insights relative to the emergence, evolution and virulence of pathogenic enterobacteria. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Keywords

Salmonella, Pathogenicity island, Excision, Virulence

Citation

Nieto P, Pardo C, Salazar F, Tobar H, Coronado I, Riedel C, Kalergis A, Bueno S. New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence. Microbes And Infection. 2016;18(5):302-309.