Browsing by Author "Salazar Echegarai, Francisco Javier"
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- ItemA Novel Live Vector Group A Streptococcal emm Type 9 Vaccine Delivered Intranasally Protects Mice against Challenge Infection with emm Type 9 Group A Streptococci(2014) Wozniak Banchero, Aniela; García Cañete, Patricia; Geoffroy, Enrique A.; Aguirre, Daniel B.; González, Samantha; Sarno, Victoria A.; Dale, James B.; Salazar Echegarai, Francisco Javier; Vera, Andrea Magdalena; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemClinical and microbiological response of mice to intranasal inoculation with Lactococcus lactis expressing Group A Streptococcus antigens, to be used as an anti-streptococcal vaccine(2018) García Cañete, Patricia; Paillavil, Braúlio A.; Scioscia, Natalia; Dale, James B.; Legarraga Raddatz, Paulette; Salazar Echegarai, Francisco Javier; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes; Wozniak Banchero, Aniela
- ItemComparative and phylogenetic analysis of a novel family of Enterobacteriaceae-associated genomic islands that share a conserved excision/integration module(2018) Piña Iturbe, Luis Alejandro; Ulloa Allendes, Diego.; Pardo Roa, Catalina; Coronado Arrázola, Irenice; Salazar Echegarai, Francisco Javier; Sclavi, Bianca.; González, Pablo A.; Bueno Ramírez, Susan
- ItemConjugal transfer of the pathogenicity island ROD21 in Salmonella enterica serovar enteritidis depends on environmental conditions(2014) Salazar Echegarai, Francisco Javier; Tobar Durán, Hugo Eduardo; Nieto Pacheco, Pamela Andrea; Bueno Ramírez, Susan
- ItemInterleukin 10 modulation of neutrophil subsets infiltrating lungs during streptococcus pneumoniae infection(2018) Peñaloza Cerda, Hernán F.; Salazar Echegarai, Francisco Javier; Bueno Ramírez, Susan
- ItemInterleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae(2015) Peñaloza, Hernán F.; Nieto Pacheco, Pamela Andrea; Muñoz Durango, Natalia; Salazar Echegarai, Francisco Javier; Torres Montes, Paula Javiera; Parga Ponce, María José; Álvarez Lobos, Manuel; Riedel, Claudia A.; Kalergis Parra, Alexis Mikes; Bueno Ramírez, Susan
- ItemInterleukin-10 Produced by Myeloid-Derived Suppressor Cells Provides Protection to Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 by Enhancing Its Clearance in the Airways(2019) Peñaloza Cerda, Hernán F.; Noguera Mijares, Loreani Paola; Ahn, D.; Vallejos, Omar; Castellanos, Raquel M.; Vazquez, Yaneisi; Salazar Echegarai, Francisco Javier; González Carreño, Liliana; Suazo Gálvez, Isidora del Carmen; Pardo Roa, Catalina; Salazar, Geraldyne; Prince, Alice; Bueno Ramírez, SusanCarbapenem-resistant Klebsiella pneumoniae sequence type 258 (CRKP-ST258) can cause chronic infections in lungs and airways, with repeated episodes of bacteremia. In this report we addressed whether the recruitment of myeloid cells producing the anti-inflammatory cytokine interleukin-10 (IL-10) modulates the clearance of CKRP-ST258 in the lungs and establishes bacterial persistence. Our data demonstrate that during pneumonia caused by a clinical isolate of CRKP-ST258 (KP35) there is an early recruitment of monocyte-myeloid-derived suppressor cells (M-MDSCs) and neutrophils that actively produce IL-10. However, M-MDSCs were the cells that sustained the production of IL-10 over the time of infection evaluated. Using mice unable to produce IL-10 (IL-10-/-), we observed that the production of this cytokine during the infection caused by KP35 is important to control bacterial burden, to prevent lung damage, to modulate cytokine production, and to improve host survival. Importantly, intranasal transfer of bone marrow-derived M-MDSCs from mice able to produce IL-10 at 1 day prior to infection improved the ability of IL-10-/- mice to clear KP35 in the lungs, decreasing their mortality. Altogether, our data demonstrate that IL-10 produced by M-MDSCs is required for bacterial clearance, reduction of lung tissue damage, and host survival during KP35 pneumonia.
- ItemMucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice(2019) Berkowitz Fiebich, Loni; Pardo Roa, Catalina; Salazar, Geraldine A.; Salazar Echegarai, Francisco Javier; Miranda Marín, José Patricio; Ramirez, Gigliola; Chávez, José L.; Kalergis Parra, Alexis Mikes; Bueno Ramírez, Susan; Alvarez Lobos, M.
- ItemPathogenicity island excision during an infection by Salmonella enterica serovar Enteritidis is required for crossing the intestinal epithelial barrier in mice to cause systemic infection(2019) Pardo Roa, Catalina; Salazar, G.A.; Noguera, L.; Salazar Echegarai, Francisco Javier; Vallejos, O.P.; Suazo Gálvez, Isidora del Carmen; Schultz, B.M.; Coronado Arrázola, Irenice; Kalergis Parra, Alexis Mikes; Bueno Ramírez, Susan
- ItemPersistent salmonella enterica serovar typhimurium infection increases the susceptibility of mice to develop intestinal inflammation(2018) Schultz, B.; Salazar, G.; Paduro, C.; Pardo Roa, Catalina; Pizarro, D.; Salazar Echegarai, Francisco Javier; Torres Montes, Paula Javiera; Riedel, C.; Kalergis Parra, Alexis Mikes; Álvarez Lobos, Manuel; Bueno Ramírez, Susan
- ItemProtective immunity induced by an intranasal multivalent vaccine comprising 10 Lactococcus lactis strains expressing highly prevalent M-protein antigens derived from Group A Streptococcus(2018) Wozniak Banchero, Aniela; Scioscia, Natalia; García Cañete, Patricia; Dale, James B.; Paillavil, Braulio A.; Legarraga Raddatz, Paulette; Salazar Echegarai, Francisco Javier; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes