Solvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity

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dc.contributor.authorPessoa Mahana, Hernan
dc.contributor.authorKosche, Johann
dc.contributor.authorRon, Nadia
dc.contributor.authorRecabarren Gajardo, Gonzalo
dc.contributor.authorSaitz, Claudio
dc.contributor.authorAraya Maturana, Rarniro
dc.contributor.authorPessoa Mahana, David
dc.date.accessioned2024-01-10T14:21:42Z
dc.date.available2024-01-10T14:21:42Z
dc.date.issued2008
dc.description.abstractA novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).
dc.description.funderProyecto FONDECYT 1050289
dc.description.funderProyecto MECESUP UCH 0116 de la Red Nacional de Doctorado en Quimica, for High Resolution Mass Spectra Analysis
dc.fechaingreso.objetodigital2024-05-30
dc.format.extent17 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3987/COM-08-11326
dc.identifier.eissn1881-0942
dc.identifier.issn0385-5414
dc.identifier.urihttps://doi.org/10.3987/COM-08-11326
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79755
dc.identifier.wosidWOS:000259131300003
dc.information.autorucQuímica;Pessoa-Mahana D;S/I;76905
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1929
dc.pagina.inicio1913
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaHETEROCYCLES
dc.rightsacceso restringido
dc.subjectdepression
dc.subjectMichael addition
dc.subjectserotonin
dc.subjectbenzothiophene
dc.subjectarylpiperazine
dc.subjectMICHAEL ADDITION
dc.subjectRECEPTOR
dc.subjectDERIVATIVES
dc.subjectQUINONES
dc.subject4-ARYLPIPERAZINES
dc.subjectIRRADIATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSolvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity
dc.typeartículo
dc.volumen75
sipa.codpersvinculados76905
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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Solvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity.pdf
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