Solvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity

Pessoa Mahana, Hernan; Kosche, Johann; Ron, Nadia; Recabarren Gajardo, Gonzalo; Saitz, Claudio; Araya Maturana, Rarniro; Pessoa Mahana, David

Solvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity

Date

2008

Authors

Pessoa Mahana, Hernan

Kosche, Johann

Ron, Nadia

Recabarren Gajardo, Gonzalo

Saitz, Claudio

Araya Maturana, Rarniro

Pessoa Mahana, David

Publisher

PERGAMON-ELSEVIER SCIENCE LTD

Abstract

A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).

Keywords

depression, Michael addition, serotonin, benzothiophene, arylpiperazine, MICHAEL ADDITION, RECEPTOR, DERIVATIVES, QUINONES, 4-ARYLPIPERAZINES, IRRADIATION