Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study

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dc.catalogadorgjm
dc.contributor.authorVaz Ferreira, Catalina
dc.contributor.authorCaro, Jose
dc.contributor.authorVillarroel del Pino, Luis A.
dc.contributor.authorMuñoz, Sergio
dc.contributor.authorÁlvarez, Patricia
dc.contributor.authorFlores, Gerardo
dc.contributor.authorHerrera, Tamara
dc.contributor.authorToso, Alberto
dc.contributor.authorToso Milos, Paulina Alejandra
dc.contributor.authorTapia Illanes, José Luis
dc.contributor.otherNEOCOSUR Neonatal Network
dc.date.accessioned2024-06-11T20:15:32Z
dc.date.available2024-06-11T20:15:32Z
dc.date.issued2024
dc.description.abstractObjective: To explore the association between antenatal magnesium sulfate (MgSO4), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants. Study design: Retrospective, cohort study of infants <32 weeks’ GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities. Results: 7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49–0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50–0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72–1.71]). No differences between groups were observed in rates of morbidities. Conclusion: Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.
dc.fuente.origenORCID
dc.identifier.doi10.1038/s41372-024-02025-y
dc.identifier.urihttps://doi.org/10.1038/s41372-024-02025-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86734
dc.information.autorucEscuela de Medicina; Villarroel del Pino, Luis A.; 0000-0001-9603-937X; 77182
dc.information.autorucEscuela de Medicina; Toso, Alberto; 0000-0002-3809-2567; 238020
dc.information.autorucEscuela de Medicina; Toso Milos, Paulina Alejandra; S/I; 1001239
dc.information.autorucEscuela de Medicina; Tapia Illanes, José Luis; S/I; 99000
dc.nota.accesocontenido parcial
dc.revistaJournal of Perinatology
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAntenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study
dc.typeartículo
sipa.codpersvinculados77182
sipa.codpersvinculados238020
sipa.codpersvinculados1001239
sipa.codpersvinculados99000
sipa.trazabilidadORCID;2024-06-10
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