Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study

Vaz Ferreira, Catalina; Caro, Jose; Villarroel del Pino, Luis A.; Muñoz, Sergio; Álvarez, Patricia; Flores, Gerardo; Herrera, Tamara; Toso, Alberto; Toso Milos, Paulina Alejandra; Tapia Illanes, José Luis

Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study

Date

2024

Authors

Vaz Ferreira, Catalina

Caro, Jose

Villarroel del Pino, Luis A.

Toso Milos, Paulina Alejandra

Tapia Illanes, José Luis

Abstract

Objective: To explore the association between antenatal magnesium sulfate (MgSO4), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants. Study design: Retrospective, cohort study of infants <32 weeks’ GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities. Results: 7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49–0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50–0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72–1.71]). No differences between groups were observed in rates of morbidities. Conclusion: Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.