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    Reinforcement Learning Based Whale Optimizer
    (Springer International, 2021) Becerra Rozas, Marcelo; Lemus Romani, José Isaac; Crawford, Broderick; Soto, Ricardo; Cisternas Caneo, Felipe; Embry, Andres Trujillo; Molina, Maximo Arnao; Tapia, Diego; Castillo, Mauricio; Misra, Sanjay; Rubio, Jose Miguel
    This work proposes a Reinforcement Learning based optimizer integrating SARSA and Whale Optimization Algorithm. SARSA determines the binarization operator required during the metaheuristic process. The hybrid instance is applied to solve benchmarks of the Set Covering Problem and it is compared with a Q-learning version, showing good results in terms of fitness, specifically, SARSA beats its Q-Learning version in 44 out of 45 instances evaluated. It is worth mentioning that the only instance where it does not win is a tie. Finally, thanks to graphs presented in our results analysis we can observe that not only does it obtain good results, it also obtains a correct exploration and exploitation balance as presented in the referenced literature.
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    A New Learnheuristic: Binary SARSA - Sine Cosine Algorithm (BS-SCA)
    (Springer Science and Business Media Deutschland GmbH, 2022) Becerra-Rozas, Marcelo; Lemus Romani, José Isaac; Crawford, Broderick; Soto, Ricardo; Cisternas Caneo, Felipe; Trujillo Embry, Andrés; Arnao Molina, Máximo; Tapia, Diego; Castillo, Mauricio; Rubio, José Miguel
    This paper proposes a novel learnheuristic called Binary SARSA - Sine Cosine Algorithm (BS-SCA) for solving combinatorial problems. The BS-SCA is a binary version of Sine Cosine Algorithm (SCA) using SARSA to select a binarization operator. This operator is required due SCA was created to work in continuous domains. The performance of BS-SCA is benchmarked with a Q-learning version of the learnheuristic. The problem tested was the Set Covering Problem and the results show the superiority of our proposal.
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    Una mirada de inclusión social y productiva para la región del Maule
    (2019) Cerecera Cabalin, Francisco Esteban; Ojeda Fuentes, Betsy; Morales Arenas, Daniela; Castillo Cortés, Miguel
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    Epidemiology of Invasive Fungal Disease by Aspergillus in a University Hospital in Santiago – Chile, During the Period 2005–2015
    (2017) Valenzuela García, Pablo Tomás; Rabagliati Borie, Ricardo Miguel; Legarraga Raddatz, Paulette
    This retrospective study analyzes invasive fungal disease (IFD) caused by *Aspergillus* in hospitalized adults at a Chilean center from 2005 to 2015. A total of 67 cases were identified, with an incidence of 2.53 per 10,000 discharges. The majority of cases were caused by *A. fumigatus* (42%), and most patients were male (55%) with a mean age of 51 years. Hematological conditions were present in 57% of patients, and 37% had neutropenia. Pulmonary involvement was the most common clinical presentation (73%). The mortality rate at 30 days was 39%. The findings align with global trends in vulnerable populations, highlighting the need for further epidemiological data to better understand *Aspergillus* infections in Chile.
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    Actividad sinérgica de ceftazidima- avibactam y aztreonam en stenotrophomonas maltophilia pan-resistente: reporte de un caso
    (2020) Reyes Barros, Tomás Alejandro; Castro Penna, Josefina; Vargas Muñoz, Camila Daniela; Rodríguez, Nicolás; Valenzuela García, Pablo Tomás; García, Patricia