Artículos de revistas

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https://repositorio.uc.cl/handle/11534/1156

Esta colección incluye artículos de revistas de profesores de la Pontificia Universidad Católica de Chile, publicados en revistas nacionales y extranjeras.

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1,1′:4′,1′′-Terphenyl-2′,5′-dicarb-oxy- lic acid dimethyl sulfoxide-d6 disolvate
(2012) Pop, L.C.; Preite, Marcelo Daniel; Manríquez M., Juan Manuel; Vega, A.; Chávez Madariaga, Ivonne
1,2,3,4,5-PENTAMETHYLCYCLOPENTADIENE
(1982) Manríquez M., Juan Manuel; Fagan, Paul J.; Schertz, Larry D.; Marks, Tobin J.; Bercaw, John; Mcgrady, Nancy
1,4-Dihydropyridines: Reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation
(2004) Valenzuela, V.; Santander, P.; Camargo, C.; Squella, J.A.; López Alarcón, Camilo Ignacio; Nuñez Vergara, L.J.
1-[1-(4-Chlorobenzenesulfonyl)-1H-indole-3-yl]-3[4-(pyridin-2-yl)piperazin-1-yl]propan-1-one
(2018) Diethelm Varela, Benjamín Manuel; Almendras Riesco, Sebastián Ignacio; Recabarren Gajardo, Gonzalo
1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole derivatives: A novel approach to the development of new HIV-1 reverse transcriptase inhibitors
(2007) Vásquez Velásquez, David; Lagos Arévalo, Carlos Fernando; Mella Raipán, Jaime Alberto; González Contreras, Luis Gerardo; Ebensperger González, Roberto Alejandro; Alvarez Figueroa, María Javiera; Sáez Moya, Edmundo Alfredo; Pessoa Mahana, Hernán; Araya Secchi, Raul; Gonzalez Wong, Angel; Perez-Acle, Tomas; Pessoa Mahana, Carlos David
10 Years of Digital Journalism (Studies): The Past, the Present, the Future
(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2023) Westlund, Oscar; Hess, Kristy; Saldana, Magdalena; Tandoc, Edson C.
The Digital Journalism editorial team is thrilled to introduce this 10th anniversary special issue. At the beginning of 2022, we invited our international editorial board to contribute to this important collection, which aims to explore the diverse and multi-disciplinary nature of digital journalism studies. We called for contributions that consider the "big picture" of the field and look at the past and the present of digital journalism studies. We also invited articles focusing on digital journalism studies for the future, considering trends, concepts, theories, methodologies, and key issues that will shape research in the decades ahead. This special issue features six articles, advancing systematic empirical assessments of developments in the field, as well as critical discussions around the developments and politics of digital journalism studies.
10-MV SBRT FFF irradiation technique is associated to the lowest peripheral dose: the outcome of 142 treatment plans for the 10 most common tumour locations
(2019) Irazola, Leticia; Sánchez Nieto, Beatriz; García Hernández, M. T.; Terrón, J. A.; Roselló, J.; Ortiz-Seidel, M.; Béjar, M. J.; Linares, Rafael; Velázquez, Santiago; Sánchez Doblado, Francisco
10-year experience in patients operated for acute invasive fungal rhinosinusitis
(2020) Lagos, A.; Ferrada, S.; Muñoz, T.; Maul Fonseca, Ximena; Finkelstein, A.; González, C.; Fonseca Arrieta, María Ximena; Callejas Canepa, Claudio Andrés
100 covers, 100 possibilities
(2018) Valenzuela M, Carolina
100% Efficient three-dimensional coronary MR angiography with two-dimensional beat-to-beat translational and bin-to-bin affine motion correction
(2015) Aitken, A.; Henningsson, M.; Botnar, René Michael; Schaeffter, T.; Prieto Vásquez, Claudia
100krad/s endless polarisation tracking with miniaturised module card
(2011) Koch, Benjamin; Noé, R.; Mirvoda, V.; Sandel, D.
11 beta-hydroxysteroid dehydrogenase activity in patients with hypertension and low plasma renin activity
(2002) Mosso, L; Carvajal, C; Campino, C; Rojas, A; Gonzalez, A; Barraza, A; Montero, J; Fardella, C; NCD Risk Factor Collaboration (NCD-RisC)
Background: Half of hypertensive patients with, low plasma renin activity have a primary hyperaldosteronism. Among the remaining half 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) deficiency plays all important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with, the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11betaSHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ug/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum. cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between, 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1 +/- 3.3 and 9.2 +/- 2.8 mug/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4 +/- 1.3 and 3.7 +/- 1.2 μg/dl, respectively). Four hypertensive subjects bad all abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with, low plasma renin activity and aldosterone had biochemical alterations suggestive of 11.1βHSD2 deficiency.
11 beta-Hydroxysteroid Dehydrogenase Type 1 is Overexpressed in Subcutaneous Adipose Tissue of Morbidly Obese Patients
(SPRINGER, 2009) Munoz, Rodrigo; Carvajal, Cristian; Escalona, Alex; Boza, Camilo; Perez, Gustavo; Ibanez, Luis; Fardella, Carlos
11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) enzyme catalyzes interconversion of inactive cortisone to active cortisol. Its expression in adipose tissue has been associated with obesity and some of its metabolic disorders. Controversies regarding which fat depots [subcutaneous adipose tissue (SAT) or visceral adipose tissue (VAT)] have higher expression still remain. The aim of this work was to evaluate 11 beta-HSD1 expression in SAT and VAT of obese patients and evaluate its association to metabolic features of metabolic syndrome.
11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension
(HUMANA PRESS INC, 2010) Campino, Carmen; Carvajal, Cristian A.; Cornejo, Javiera; San Martin, Betty; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Francesco; Sateler, Javiera; Baudrand, Rene; Mosso, Lorena; Owen, Gareth I.; Kalergis, Alexis M.; Padilla, Oslando; Fardella, Carlos E.
Cortisol availability is modulated by several enzymes: 11 beta-HSD2, which transforms cortisol (F) to cortisone (E) and 11 beta-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5 alpha- and 5 beta-reductase) inactivate cortisol (together with 3 alpha-HSD) to tetrahydrometabolites: 5 alpha THF, 5 beta THF, and THE. The aim was to assess 11 beta-HSD2, 11 beta-HSD1, and 5 beta-reductase activity in hypertensive patients. Free urinary F, E, THF, and THE were measured by HPLC-MS/MS in 102 essential hypertensive patients and 18 normotensive controls. 11 beta-HSD2 enzyme activity was estimated by the F/E ratio, the activity of 11 beta-HSD1 in compare to 11 beta-HSD2 was inferred by the (5 alpha THF + 5 beta THF)/THE ratio and 5 beta-reductase activity assessed using the E/THE ratio. Activity was considered altered when respective ratios exceeded the maximum value observed in the normotensive controls. A 15.7% of patients presented high F/E ratio suggesting a deficit of 11 beta-HSD2 activity. Of the remaining 86 hypertensive patients, two possessed high (5 alpha THF + 5 beta THF)/THE ratios and 12.8% had high E/THE ratios. We observed a high percentage of alterations in cortisol metabolism at pre-receptor level in hypertensive patients, previously misclassified as essential. 11 beta-HSD2 and 5 beta-reductase decreased activity and imbalance of 11 beta-HSDs should be considered in the future management of hypertensive patients.
11β-hydroxysteroid dehydrogenase activity in patients with hypertension and low plasma renin activityActividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
(2002) Fardella B C.; Mosso G L.; Carvajal M C.; Campino J C.; Rojas O A.; González P A.; Barraza M A.; Montero L J.; NCD Risk Factor Collaboration (NCD-RisC)
Background: Half of hypertensive patients with low plasma renin activity have a primary hyperaldosteronism. Among the remaining half, 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) deficiency plays an important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11βHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ng/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1±3.3 and 9.2±2.8 μg/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4±1.3 and 3.7±1.2 μg/dl, respectively). Four hypertensive subjects had an abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with low plasma renin activity and aldosterone had biochemical alterations suggestive of 11βHSD2 deficiency (Rev Méd Chile 2002; 130: 1201-8).
11β-hydroxysteroid dehydrogenase type 2 polymorphisms and activity in a Chilean essential hypertensive and normotensive cohort.
(2012) Campino, Carmen; Quinteros, Hector; Owen, Gareth I.; Carvajal, Cristian A.; Morales, Mauricio; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Francesco; Baudrand, Rene; Padilla, Oslando; Valdivia, Carolina; Thichauer, Juan; Lagos, Carlos F.; Kalergis, Alexis M.; Fardella, Carlos E.
BACKGROUND: 11β-hydroxysteroid dehydrogenase type 2 enzyme (11β-HSD2) inactivates cortisol (F) to cortisone (E); its impairment is associated with hypertension. We reported that 15.7% of the Chilean essential hypertensives possessed a high F/E ratio suggesting a partial deficit in 11β-HSD2 activity. It has been reported that the G534A(Glu178/Glu) polymorphism in the HSD11B2 gene is associated with hypertension. Investigate the frequency of the G534A polymorphism and its correlation with the glucocorticoid profile in Chilean essential hypertensive and normotensive subjects. METHODS: Essential hypertensive outpatients (n = 232) and normotensive subjects (n = 74) were recruited. A change in the AluI restriction enzyme digest pattern, caused by the presence of the G534A polymorphism, was utilized to screen DNA isolated from leukocytes within the cohort before confirmation by sequencing. Plasma renin activity (PRA), serum aldosterone, F, and E were measured by radioimmunoassay. Urinary tetrahydrocortisol (THF), 5α-tetrahydrocortisol (5α-THF), and tetrahydrocortisone (THE) were measured by gas chromatography-mass spectrometry. RESULTS: G534A polymorphism frequency was similar between hypertensive patients (19 of 232; 8.2%) and normotensive subjects (7 of 74; 9.5%). When categorized by presence or absence of the G534A polymorphism, no significant differences in the serum F/E ratio or other measured biochemical variables were detected. Despite a previous report that the G534A polymorphism is associated with a neighboring C468A (Thr156/Thr) polymorphism, analysis within our cohort showed that only one patient in each group presented with this double polymorphism. CONCLUSIONS: We report the frequency of the G534A polymorphism in the Spanish-Amerindian population. No correlation was detected between this polymorphism and the presence of hypertension and biochemical parameters in this Chilean cohort.
12 year single center retrospective review of risk factors and rate of tined lead breakage during sacral neuromodulation lead explant
(2019) Rueb, Jessica; Pizarro Berdichevsky, Javier Alejandro; Derisavifard, Samir; Giusto, Laura; Zahner, Patricia; Mor, Courtenay; Rackley, Raumond; Vasavada, Sandip; Goldman, Howard
The tined lead for use with InterStim sacral neuromodulation (SNM) was introduced in 2002. However, little data on lead breakage has been published. In 2010 the manufacturer estimated a 1% rate of lead breakage and recommended removal from an incision over the sacrum (as opposed to from generator site). We previously described 5-year data of an 18% rate of lead breakage with risk factors of time since implantation and diabetes. The purpose of this review was to extend this data, and further define rate and risk factors for lead breakage.
120 puertas.
(2005) Pezo Bravo, Mauricio Andrés; Ellrichshausen, Sofía von.
12CO(J=3→2) detections in bulges of low surface brightness galaxies with APEX
(2008) Galaz, Gaspar; Galaz, Gaspar
(13)C NMR studies of heterocyclic naphtho- and anthraquinones. Deshielding effect on the carbonyl carbon with methyl substitution
(2008) Salas Sánchez, Cristián Osvaldo; Armstrong Lattapiat, Ana Verónica; López Astorga, Claudio; Tapia Apati, Ricardo

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