Cryptogenic organizing pneumonitis during oxaliplatin chemotherapy for colorectal cancer - Case report

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dc.contributor.authorGarrido, Marcelo
dc.contributor.authorO'Brien, Andres
dc.contributor.authorGonzalez, Sergio
dc.contributor.authorClavero, Jose Mignel
dc.contributor.authorOrellana, Eric
dc.date.accessioned2024-01-10T12:04:47Z
dc.date.available2024-01-10T12:04:47Z
dc.date.issued2007
dc.description.abstractThe patient presented here is a 30-year-old woman who underwent anterior resection for the initial treatment of rectal cancer. A postoperative study showed a single liver metastasis. The patient received adjuvant pelvic radiotherapy with concomitant 5-fluorouracil (5-FU) treatment followed by liver metastasectomy 6 weeks after the completion of radiation therapy and chemotherapy. Adjuvant therapy with 5-FU, leucovorin, and oxaliplatin (FOLFOX 4 regimen) was continued. The initial five cycles were well tolerated with the occurrence of only paresthesia that did not interfere with function. After the sixth cycle of the treatment, progressive dyspnea and persistent cough developed in the patient, although her clinical history was negative for lung disease. A chest radiograph revealed diffuse bilateral interstitial infiltrates, and a chest CT scan showed bilateral alveolar infiltrates predominant in the right lung. Lung biopsy by video-assisted thoracoscopy was performed, and the histologic report showed cryptogenic organizing pneumonitis (COP). Prednisone therapy (1 mg/kg/d) resulted in a very good clinical response. In fact, the patient had complete remission of respiratory symptoms including cough and dyspnea after 4 days of treatment, and the chest CT scan showed complete resolution of lung infiltrates after 4 weeks. One month later, the patient continued adjuvant treatment with six cycles of 5-FU, leucovorin, and irinotecan (ie, the FOLFIRI regimen) without complications. Thus, oxiplatin was implicated as the likely cause of this drug-induced lung toxicity, which is a very rare complication associated with platins. Diffuse interstitial lung disease, particularly COP, has been described following the administration of the cytotoxic agents bleomycin and busulfan, but a connection to oxaliplatin has not been reported before this case.
dc.format.extent3 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1378/chest.07-0536
dc.identifier.issn0012-3692
dc.identifier.pubmedidMEDLINE:18079234
dc.identifier.urihttps://doi.org/10.1378/chest.07-0536
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75880
dc.identifier.wosidWOS:000251996900045
dc.information.autorucMedicina;Clavero J;S/I;3195
dc.information.autorucMedicina;Garrido M;S/I;7260
dc.information.autorucMedicina;González S;S/I;99856
dc.information.autorucMedicina;O'Brien A;S/I;1261
dc.information.autorucMedicina;Orellana E;S/I;96947
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1999
dc.pagina.inicio1997
dc.publisherAMER COLL CHEST PHYSICIANS
dc.revistaCHEST
dc.rightsregistro bibliográfico
dc.subjectcolorectal cancer
dc.subjectcryptogenic organizing pneumonitis
dc.subjectoxaliplatin
dc.subject5-FLUOROURACIL
dc.subjectFLUOROURACIL
dc.subjectDISEASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCryptogenic organizing pneumonitis during oxaliplatin chemotherapy for colorectal cancer - Case report
dc.typeartículo
dc.volumen132
sipa.codpersvinculados3195
sipa.codpersvinculados7260
sipa.codpersvinculados99856
sipa.codpersvinculados1261
sipa.codpersvinculados96947
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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