SARS-CoV-2 Antibody Prevalence among 85,529 Healthcare Workers following the First Wave of COVID-19 in Chile

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dc.catalogadorgjm
dc.contributor.authorZuñiga, Marcela
dc.contributor.authorO'Ryan, Miguel
dc.contributor.authorBertoglia, María Paz
dc.contributor.authorBravo Valenzuela, Paulina Fabiola
dc.contributor.authorLagomarcino, Anne J.
dc.contributor.authorMuñoz, Sergio
dc.contributor.authorPeña Alonso, Alfredo
dc.contributor.authorRodriguez, María Andrea
dc.contributor.authorVial, Pablo A.
dc.date.accessioned2023-05-19T20:24:53Z
dc.date.available2023-05-19T20:24:53Z
dc.date.issued2021
dc.description.abstractBackground: Healthcare workers (HCWs) are at increased risk for SARS-CoV-2 infection, however not all face the same risk. We aimed to determine antibody prevalence and risk factors associated with seropositivity in the Chilean HCW community. Methods: This was a nationwide, cross-sectional study consisting of a questionnaire and COVID-19 antibody testing. All HCWs in the Chilean public health care system were invited to participate three to four months following the peak of the country's first wave. Findings: Overall SARS-Cov-2 blood antibody positivity by fingerstick or venipuncture in 85 529 HCWs was 7 · 2%, ranging from 1 · 6% to 12 · 4% between regions. SARS-Cov-2 positive PCR results were self-reported in 8 330 individuals (9 · 7%) of which 47% were seropositive. Overall 10 863 (12 · 7%) either reported prior PCR positive results and/or were seropositive. Several factors were independently associated with higher IRR for seropositivity, including working in hospital (IRR 1·484), medicine/surgery w ards (IRR 1·383), emergency room (IRR 1·266), and night shifts (IRR 1·616), as were history of contact with a confirmed case (IRR 1·462), and use of public transport (IRR 1·367). These variables remained significant when including self-reported PCR positive cases in the model. Interpretation: HCWs in the hospital were at highest risk for COVID-19, especially if working in medicine/surgery wards or emergency rooms, in night shifts, older age, exposed to confirmed cases and/or using public transport. Antibody results using lateral flow likely underestimated true infection rates by nearly 40-50%. Nevertheless, risk factors were sustained when adjusting for self-reported PCR positive cases.
dc.fechaingreso.objetodigital2023-07-14
dc.format.extent18 páginas
dc.fuente.origenORCID
dc.identifier.doi10.2139/ssrn.3785998
dc.identifier.urihttps://papers.ssrn.com/sol3/papers.cfm?abstract_id=3785998
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67185
dc.information.autorucEscuela de Enfermería; Bravo Valenzuela, Paulina Fabiola; 0000-0001-7378-6487; 132721
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subjectHealthcare workerses_ES
dc.subjectCOVID-19es_ES
dc.subjectAntibody prevalencees_ES
dc.subjectVaccine priorityes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleSARS-CoV-2 Antibody Prevalence among 85,529 Healthcare Workers following the First Wave of COVID-19 in Chilees_ES
dc.typepreprint
sipa.codpersvinculados132721
sipa.trazabilidadORCID;14-07-2023
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