The Dynamic Relationship Between End-Tidal Sevoflurane Concentrations, Bispectral Index, and Cerebral State Index in Children

Simple item page
dc.contributor.authorFuentes, Ricardo
dc.contributor.authorCortinez, Luis I.
dc.contributor.authorStruys, Michel M. R. F.
dc.contributor.authorDelfino, Alejandro
dc.contributor.authorMunoz, Hernan
dc.date.accessioned2024-01-10T14:21:56Z
dc.date.available2024-01-10T14:21:56Z
dc.date.issued2008
dc.description.abstractBACKGROUND: To guide anesthetic administration with electroencephalogram monitors in children, an adequate characterization of the anesthetic effect measured by these monitors in this population is needed. We sought to quantify and compare the dynamic profile of sevoflurane's effect measured with the cerebral state index (CST) and the bispectral index (BIS) in children.
dc.description.abstractMETHODS: Fifteen healthy children, aged 3-15 yr, scheduled to undergo minor surgery were prospectively studied. During the simultaneous recording of CST and % for 5 min and then decreased. BIS, the sevoflurane vaporizer was set at 6 vol End-tidal concentrations (C-ET) were measured. The C-ET-sevoflurane effect-site concentration equilibration and pharmacodynamics were modeled. Goodness of fit between models was compared. Data are typical value (coefficient of variation).
dc.description.abstractRESULTS: Within the anesthetic depth range studied, the rate of change of sevoflurane's effect expressed as the effect-site equilibration half-life (t(1/2) k(e0)) was slower with the CST [2.0 (14) min] than with BIS [1.2 (53) min] (P < 0.05). The estimated baseline effect of BIS and CST before sevoflurane administration (E-0) was 84 (39) for CST and 87 (7) for BIS (NS). The sensitivity to sevoflurane hypnotic effect expressed in the C-50 [steady-state C-ET eliciting half of the maximum response (E-max)] was 2.1 (68) % with CST and 2.1. (16)% with BIS (NS). The E-max with CST 45 (0) was higher than that with BIS 27 (39) (P < 0.05). The population prediction error was significantly better for BIS (-0.7 +/- 26.9) than for CST (-3.0 +/- 178.6) (P < 0.05).
dc.description.abstractCONCLUSIONS: In children, the t(1/2) k(e0) of sevoflurane and the pharmacodynamics of sevoflurane were quantified and the results were entirely dependent on the monitor used to measure its hypnotic effect. Within the anesthetic depth range studied, the rate of change of sevoflurane's effect was slower with the CST. To adequately guide sevoflurane administration with these monitors in children, these differences should be considered.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1213/ane.0b013e318181ef88
dc.identifier.issn0003-2999
dc.identifier.pubmedidMEDLINE:18931214
dc.identifier.urihttps://doi.org/10.1213/ane.0b013e318181ef88
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79823
dc.identifier.wosidWOS:000260397200018
dc.information.autorucMedicina;Cortínez L;S/I;79356
dc.information.autorucMedicina;Delfino A;S/I;129220
dc.information.autorucMedicina;Fuentes R;S/I;91662
dc.information.autorucMedicina;Muñoz H;S/I;73573
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1578
dc.pagina.inicio1573
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaANESTHESIA AND ANALGESIA
dc.rightsacceso restringido
dc.subjectPROPOFOL ANESTHESIA
dc.subjectCONTROLLED INFUSION
dc.subjectEEG
dc.subjectPHARMACODYNAMICS
dc.subjectPERFORMANCE
dc.subjectINFANTS
dc.subjectBIS
dc.subjectAGE
dc.titleThe Dynamic Relationship Between End-Tidal Sevoflurane Concentrations, Bispectral Index, and Cerebral State Index in Children
dc.typeartículo
dc.volumen107
sipa.codpersvinculados79356
sipa.codpersvinculados129220
sipa.codpersvinculados91662
sipa.codpersvinculados73573
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-05-15. The Dynamic Relationship Between End-Tidal Sevoflurane Concentrations, Bispectral Index, and Cerebral State Index in Children.pdf
Size:
3.48 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas