Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure

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dc.contributor.authorLuis Winter, Jose
dc.contributor.authorCastro, Pablo
dc.contributor.authorMeneses, Luis
dc.contributor.authorChalhub, Monica
dc.contributor.authorVerdejo, Hugo
dc.contributor.authorGreig, Douglas
dc.contributor.authorGabrielli, Luigi
dc.contributor.authorChiong, Mario
dc.contributor.authorConcepcion, Roberto
dc.contributor.authorMellado, Rosemarie
dc.contributor.authorHernandez, Claudia
dc.contributor.authorUribe, Sergio
dc.contributor.authorLavander, Sergio
dc.date.accessioned2024-01-10T12:06:49Z
dc.date.available2024-01-10T12:06:49Z
dc.date.issued2010
dc.description.abstractBackground: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HE Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in five patients with non-ischemic heart failure, aged 58 +/- 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: Among patients, left ventricular ejection fraction was 32 +/- 6.9%, 60% were in functional capacity II, 60% had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/Cr index, among patients with heart failure, when compared with healthy controls (1.46 +/- 1.21 and 5.96 +/- 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 +/- 2.66 and 1.80 +/- 1.62 respectively, p = 0.08). Conclusions: Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy. (Rev Med Chile 2010; 138: 1475-1479).
dc.fechaingreso.objetodigital2024-06-14
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872010001300001
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:21526294
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76210
dc.identifier.wosidWOS:000286684600001
dc.information.autorucMedicina;Douglas Greig;S/I;15418
dc.information.autorucMedicina;Hugo Verdejo;S/I;1001175
dc.information.autorucMedicina;José Luis Winter;S/I;15983
dc.information.autorucMedicina;Luigi Gabrielli;S/I;11086
dc.information.autorucMedicina;Luis Meneses;S/I;10742
dc.information.autorucMedicina;Pablo Castro;S/I;100212
dc.information.autorucQuímica;Rosemarie Mellado;S/I;109357
dc.information.autorucMedicina;Sergio Uribe;S/I;16572
dc.issue.numero12
dc.language.isoes
dc.nota.accesocontenido parcial
dc.pagina.final1479
dc.pagina.inicio1475
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso restringido
dc.subjectCreatine
dc.subjectHeart failure
dc.subjectMagnetic resonance spectroscopy
dc.subjectCARDIOMYOPATHY
dc.subjectDEPLETION
dc.subjectKINASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMyocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure
dc.typeartículo
dc.volumen138
sipa.codpersvinculados15418
sipa.codpersvinculados1001175
sipa.codpersvinculados15983
sipa.codpersvinculados11086
sipa.codpersvinculados10742
sipa.codpersvinculados100212
sipa.codpersvinculados109357
sipa.codpersvinculados16572
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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