Adiponectin multimers in maternal plasma

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dc.catalogadorpau
dc.contributor.authorMazaki-Tovi, S.
dc.contributor.authorRomero, R.
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorErez, O.
dc.contributor.authorVaisbuch, E.
dc.contributor.authorGotsch, F.
dc.contributor.authorMittal, P.
dc.contributor.authorThan, G. N.
dc.contributor.authorNhan-Chang, C.
dc.contributor.authorChaiworapongsa, T.
dc.contributor.authorEdwin, S.
dc.contributor.authorCamacho, N.
dc.contributor.authorNien Shy, Jyh-Kae
dc.contributor.authorHassan, S. S.
dc.date.accessioned2023-05-18T19:49:43Z
dc.date.available2023-05-18T19:49:43Z
dc.date.issued2008
dc.description.abstractObjective: Adiponectin is an anti-diabetic, anti-atherogenic, anti-inflammatory, and angiogenic adipokine that circulates in oligomeric complexes including: low molecular weight (LMW) trimers, medium molecular weight (MMW) hexamers, and high molecular weight (HMW) isoforms. The aim of this study was to determine whether there are changes in adiponectin multimers in pregnancy and as a function of maternal weight. Study design: In this cross-sectional study, plasma concentrations of total, HMW, MMW, and LMW adiponectin were determined in women included in three groups: (1) normal pregnant women of normal body mass index (BMI) (n ¼ 466), (2) overweight pregnant women (BMI 25; n ¼ 257), and (3) non-pregnant women of normal weight (n ¼ 40). Blood samples were collected once from each woman between 11 and 42 weeks of gestation. Plasma adiponectin multimer concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Non-parametric statistics were used for analysis. Results: (1) The median HMW adiponectin concentration and the median HMW/total adiponectin ratio were significantly higher, and the median LMW adiponectin concentration was significantly lower in pregnant women than in non-pregnant women. (2) Among pregnant women, the median plasma concentration of total, HMW, and MMW adiponectin was significantly higher in normal weight women than in overweight patients. (3) Maternal HMW was the most prevalent adiponectin multimer regardless of gestational age or BMI status. (4) There were no significant differences in the median concentration of total, MMW, and LMW adiponectin and their relative distribution with advancing gestation. Conclusion: Human pregnancy is characterized by quantitative and qualitative changes in adiponectin multimers, especially the most active isoform, HMW adiponectin.
dc.format.extent20 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1080/14767050802266881
dc.identifier.issn1476-7058
dc.identifier.urihttps://doi.org/10.1080/14767050802266881
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-56749154017&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67098
dc.information.autorucEscuela de Medicina; Kusanovic Pivcevic, Juan Pedro; 0000-0003-0640-2070; 1008900
dc.information.autorucEscuela de Medicina; Nien Shy, Jyh-Kae; 0000-0002-2572-9653; 2778
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final815
dc.pagina.inicio796
dc.revistaThe Journal of Maternal-Fetal & Neonatal Medicine
dc.rightsacceso abierto
dc.subjectAdiponectin
dc.subjectAdipokines
dc.subjectPregnancy
dc.subjectHigh molecular weight (HMW) adiponectin
dc.subjectMedium molecular weight (MMW) adiponectin
dc.subjectLow molecular weight (LMW) adiponectin
dc.subjectBMI
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAdiponectin multimers in maternal plasma
dc.typeartículo
dc.volumen21
sipa.codpersvinculados1008900
sipa.codpersvinculados2778
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