Uterotonics, magnesium sulphate and antibiotics during childbirth and peripartum: Important obstetric drugs for the anaesthesiologist

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dc.contributor.authorAstete, M.
dc.contributor.authorLacassie, H. J.
dc.date.accessioned2025-01-20T16:17:22Z
dc.date.available2025-01-20T16:17:22Z
dc.date.issued2024
dc.description.abstractThe main causes of maternal mortality are comorbidities, hypertensive pregnancy syndrome, obstetric haemorrhage, and maternal sepsis. For this reason, uterotonics, magnesium sulphate, and antibiotics are essential tools in the management of obstetric patients during labour and in the peripartum period. These drugs are widely used by anaesthesiologists in all departments, and play a crucial role in treatment and patient safety. For the purpose of this narrative review, we performed a detailed search of medical databases and selected studies describing the use of these drugs in patients during pregnancy, delivery and the pospartum period. Uterotonics, above all oxytocin, play an important role in the prevention and treatment of pospartum haemorrhage, and various studies have shown that in obstetric procedures, such as scheduled and emergency caesarean section, they are effective at lower doses than those hitherto accepted. We also discuss the use of carbetocin as an effective alternative that has a therapeutic advantage in certain clinical circumstances. Magnesium sulphate is the gold standard in the prevention and treatment of eclampsia, and also plays a neuroprotective role in preterm infants. We describe the precautions to be taken during magnesium administration. Finally, we discuss the importance of understanding microbiology and the pharmacology of antibiotics in the management of obstetric infection and endometritis, and draw attention to the latest trends in antibiotic regimens in labour and caesarean section. (c) 2024 Sociedad Espa & ntilde;ola de Anestesiolog & iacute;a, Reanimaci & oacute;n y Terap & eacute;utica del Dolor. Published by Elsevier Espa & ntilde;a, S.L.U. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.redar.2023.08.007
dc.identifier.eissn2340-3284
dc.identifier.issn0034-9356
dc.identifier.urihttps://doi.org/10.1016/j.redar.2023.08.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90594
dc.identifier.wosidWOS:001233575000001
dc.issue.numero5
dc.language.isoen
dc.pagina.final420
dc.pagina.inicio412
dc.revistaRevista espanola de anestesiologia y reanimacion
dc.rightsacceso restringido
dc.subjectUterine haemorrhage
dc.subjectPreeclampsia
dc.subjectEclampsia
dc.subjectAnti-bacterial agents
dc.subjectMagnesium sulphate
dc.subjectSepsis
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleUterotonics, magnesium sulphate and antibiotics during childbirth and peripartum: Important obstetric drugs for the anaesthesiologist
dc.typeartículo
dc.volumen71
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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