Food allergy markers in peptic disease

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dc.catalogadorjwg
dc.contributor.authorTalesnik Guendelman, Eduardo
dc.contributor.authorMajerson Grinberg, Daniela
dc.contributor.authorSerrano Honeyman, Carolina Andrea
dc.contributor.authorEinisman Fleiderman, Helly Jael
dc.contributor.authorAravena González, Carmen Fabiola
dc.contributor.authorPeña Villegas, Alfredo Javier
dc.contributor.authorRos Torres, Javiera Ignacia
dc.contributor.authorDuarte Garcia, De Cortázar Ignacio
dc.contributor.authorHarris Diez, Paul Richard
dc.date.accessioned2024-01-15T14:16:35Z
dc.date.available2024-01-15T14:16:35Z
dc.date.issued2009
dc.description.abstractBackground: The double-blind food challenge is the gold standard for diagnosis of food allergy, eventhough it is difficult to standardize and execute. An increase in allergy prevalence worldwide accentuates the importance of evaluating food allergy markers, in order to help the diagnosis. Objective: Elaboration of an operational definition for food hypersensitivity (FH) and evaluate the role of allergy markers, endoscopic and hystological findings, gastric mucosa cytokines and personal/family history of allergy in children. Method: Enrollment of children with suspected peptic disease referred for endoscopy. We obtained antral biopsies for hystological evaluation (eosinophil and mast cell count) and measurement of mucosal cytokines through an ELISA test. Patients were evaluated with Prick test, total serum IgE and clinical questionnaires for allergies. They were divided into two groups; children with and without food hypersensitivity. Results: 97 children were enrolled (mean: 11.7 ± 3, range 3-18). 4% of children had FH. The endoscopic findings did not correlate with the presence of FH. 74.1% of patients without FH had eosinophils in the gastric mucosa compared to groups with FH which had 100% (p < 0.05). Only IL-2 among the evaluated cytokines was found in a greater concentration in patients without FH. 33% of patients considered themselves having history of personal allergies versus 11.8% of people without FH (p < 0.05). Conclusions: 12,4% of children with digestive symptoms referred to endoscopy have FH. There are no clinical, endoscopic or hystological differences between patients with or without FH.
dc.fechaingreso.objetodigital2024-01-15
dc.fuente.origenORCID
dc.identifier.doi10.4067/S0370-41062009000200003
dc.identifier.urihttps://publons.com/wos-op/publon/55772473/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80453
dc.information.autorucEscuela de Medicina; Harris Diez Paul Richard; 0000-0001-6226-0957; 80706
dc.information.autorucEscuela de Medicina; Talesnik Guendelman Eduardo; ; 30516
dc.information.autorucEscuela de Medicina; Majerson Grinberg Daniela; ; 133956
dc.information.autorucEscuela de Medicina; Serrano Honeyman Carolina Andrea; 0000-0001-5523-0637; 15296
dc.information.autorucEscuela de Medicina; Einisman Fleiderman Helly Jael; ; 16260
dc.information.autorucEscuela de Medicina; Aravena Gonzalez Carmen Fabiola; ; 1034324
dc.information.autorucEscuela de Medicina; Peña Villegas Alfredo Javier; 0009-0009-8026-018X; 75347
dc.information.autorucEscuela de Medicina; Ros Torres Javiera Ignacia; ; 1196052
dc.information.autorucEscuela de Medicina; Duarte Garcia De Cortazar Ignacio; ; 98528
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaRevista Chilena de Pediatria
dc.rightsacceso restringido
dc.subjectAllergy
dc.subjectEosinophils
dc.subjectFood hypersensitivity
dc.subjectHypersensitivity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleFood allergy markers in peptic disease
dc.typeartículo
dc.volumen80
sipa.codpersvinculados80706
sipa.codpersvinculados30516
sipa.codpersvinculados133956
sipa.codpersvinculados15296
sipa.codpersvinculados16260
sipa.codpersvinculados1034324
sipa.codpersvinculados75347
sipa.codpersvinculados1196052
sipa.codpersvinculados98528
sipa.trazabilidadORCID;2024-01-08
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