The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial

dc.article.number144
dc.catalogadorgjm
dc.contributor.authorFigueroa Vargas, Alejandra
dc.contributor.authorGóngora, Begoña
dc.contributor.authorAlonso, María F.
dc.contributor.authorOrtega, Alonso
dc.contributor.authorSoto Fernández, Patricio
dc.contributor.authorZ-Rivera, Lucía
dc.contributor.authorRamírez, Sebastián
dc.contributor.authorGonzález, Francisca
dc.contributor.authorMuñoz Venturelli, Paula
dc.contributor.authorBilleke, Pablo
dc.date.accessioned2024-03-07T16:21:43Z
dc.date.available2024-03-07T16:21:43Z
dc.date.issued2024
dc.date.updated2024-02-25T01:03:40Z
dc.description.abstractBackground: The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia and mild cognitive impairment (MCI). The latter can be considered a prodromal phase of some dementias and a critical stage for interventions to postpone the impairment of functionality. Working memory (WM) is a pivotal cognitive function, representing the fundamental element of executive functions. This project proposes an intervention protocol to enhance WM in these users, combining cognitive training with transcranial electrical stimulation of alternating current (tACS). This technique has been suggested to enhance the neuronal plasticity needed for cognitive processes involving oscillatory patterns. WM stands to beneft signifcantly from this approach, given its welldefined electrophysiological oscillations. Therefore, tACS could potentially boost WM in patients with neurodegenerative diseases. Methods: This study is a phase IIb randomised, double-blind clinical trial with a 3-month follow-up period. The study participants will be 62 participants diagnosed with MCI, aged over 60, from Valparaíso, Chile. Participants will receive an intervention combining twelve cognitive training sessions with tACS. Participants will receive either tACS or placebo stimulation in eight out of twelve training sessions. Sessions will occur twice weekly over 6 weeks. The primary outcomes will be electroencephalographic measurements through the prefrontal theta oscillatory activity, while the secondary efects will be cognitive assessments of WM. The participants will be evaluated before, immediately after, and 3 months after the end of the intervention. Discussion: The outcomes of this trial will add empirical evidence about the benefts and feasibility of an intervention that combines cognitive training with non-invasive brain stimulation. The objective is to contribute tools for optimal cognitive treatment in patients with MCI. To enhance WM capacity, postpone the impairment of functionality, and obtain a better quality of life. Trial registration: ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered on 15 September 2023.
dc.fechaingreso.objetodigital2024-03-07
dc.format.extent14 páginas
dc.fuente.origenBiomed Central
dc.identifier.citationTrials. 2024 Feb 23;25(1):144
dc.identifier.doi10.1186/s13063-024-07972-7
dc.identifier.urihttps://doi.org/10.1186/s13063-024-07972-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84286
dc.information.autorucEscuela de Medicina; Figueroa Vargas, Alejandra; S/I; 1194381
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaTrials
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMild cognitive impairment
dc.subjectCognitive training
dc.subjectWorking memory
dc.subjectCognitive functions
dc.subjectNon-invasive brain stimulation
dc.subjectRandomised controlled trial
dc.titleThe effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial
dc.typeartículo
dc.volumen25
sipa.codpersvinculados1194381
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