Nuevos receptores nucleares heterodiméricos: reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus

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dc.contributor.authorCortés Mora, Víctor Antonio
dc.contributor.authorQuezada Sanhueza, Nicolás
dc.contributor.authorRigotti Rivera, Attilio
dc.contributor.authorMaiz Gurruchaga, Manuel Alberto
dc.date.accessioned2021-11-05T19:31:05Z
dc.date.available2021-11-05T19:31:05Z
dc.date.issued2005
dc.description.abstractThe regulation of gene expression is crucial for the normal development and the homeostatic maintenance of body tissues. Thus, its malfunction may determine a variety of human disease conditions. A growing body of evidence has shown the overwhelming relevance of a new class of gene expression regulators: the heterodimeric nuclear receptors, a family of structurally related proteins involved in multiple biological functions. In response to activating ligands, these molecules bind to specific genomic regulatory regions where they can coordinately modify the transcriptional activity of several genes involved in the main metabolic pathways of lipids and carbohydrates in cells. These functional properties have stimulated the study of the relationships between heterodimeric nuclear receptors and various disease conditions, such as dyslipidemias and diabetes mellitus. Here we review the experimental, clinical and epidemiological evidences that support the relevance of these transcriptional regulators in the pathophysiology of the most prevalent and lethal diseases in Western countries. We also explore the potential therapeutic impact of new strategies based in the pharmacological modulation of the heterodimeric nuclear receptors
dc.fuente.origenORCID
dc.identifier.issn0717-6163
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-32244445264&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/62926
dc.information.autorucEscuela de medicina ; Cortés Mora, Víctor Antonio ; 0000-0002-1658-0965 ; 7576
dc.information.autorucEscuela de medicina ; Quezada, Nicolás ; 0000-0001-6207-2753 ; 127224
dc.information.autorucEscuela de medicina ; Rigotti Rivera, Attilio ; 0000-0002-0495-3525 ; 68489
dc.information.autorucEscuela de medicina ; Maiz Gurruchaga, Manuel Alberto ; S/I ; 99116
dc.issue.numeroNo. 12
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1492
dc.pagina.inicio1483
dc.provenancejarnes 2021-11-05 16:31:04
dc.relation.isformatofRevista Médica de Chile, vol. 133, no. 12 (dic., 2005), pp. 1483 - 1492
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.subjectDiabetes mellitus
dc.subjectHyperlipidemia
dc.subjectReceptors, cytoplasmic and nuclear
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherMedicina y salud
dc.titleNuevos receptores nucleares heterodiméricos: reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus
dc.title.alternativeNew heterodimeric nuclear receptors: key metabolic regulators with relevance in the pathophysiology and therapy of dyslipidemias and diabetes mellitus
dc.typeartículo de revisión
dc.volumenVol. 133
sipa.codpersvinculados7576
sipa.codpersvinculados127224
sipa.codpersvinculados68489
sipa.codpersvinculados99116
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