Racial and ethnic disparities in the natural history of alcohol-associated liver disease in the United States

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dc.catalogadorgrr
dc.contributor.authorAyares Campos, Gustavo Ignacio
dc.contributor.authorDiaz Piga, Luis Antonio
dc.contributor.authorFuentes Lopez, Eduardo
dc.contributor.authorIdalsoaga Ferrer, Francisco Javier
dc.contributor.authorCotter, Thomas G.
dc.contributor.authorDunn, Winston
dc.contributor.authorSimonetto, Douglas
dc.contributor.authorShah, Vijay H.
dc.contributor.authorKamath, Patrick S.
dc.contributor.authorLazarus, Jeffrey V.
dc.contributor.authorBataller, Ramon
dc.contributor.authorArrese, Marco
dc.contributor.authorWong, Robert J.
dc.contributor.authorSingal, Ashwani K.
dc.contributor.authorArab, Juan Pablo
dc.date.accessioned2024-08-22T21:10:16Z
dc.date.available2024-08-22T21:10:16Z
dc.date.issued2024
dc.description.abstractBackground: Outcomes in alcohol-associated liver disease (ALD) are influenced by several race and ethnic factors, yet its natural history across the continuum of patients in different stages of the disease is unknown.MethodsWe conducted a retrospective cohort study of U.S. adults from 2011 to 2018, using three nationally representative databases to examine potential disparities in relevant outcomes among racial and ethnic groups. Our analysis included logistic and linear regressions, along with competing risk analysis.ResultsBlack individuals had the highest daily alcohol consumption (12.6 g/day) while Hispanic participants had the largest prevalence of heavy episodic drinking (33.5%). In a multivariable-adjusted model, Hispanic and Asian participants were independently associated with a higher ALD prevalence compared to Non-Hispanic White interviewees (OR: 1.4, 95% CI: 1.1-1.8 and OR: 1.5 95% CI:1.1-2.0, respectively), while Blacks participants had a lower ALD prevalence (OR: .7 95% CI: .6-.9), and a lower risk of mortality during hospitalization due to ALD (OR: .83 95% CI: .73-.94). Finally, a multivariate competing-risk analysis showed that Hispanic ethnicity had a decreased probability of liver transplantation if waitlisted for ALD (SHR: .7, 95% CI: .6-.8) along with female Asian population (HR: .40, 95% CI: .26-.62).ConclusionsAfter accounting for key social and biological health determinants, the Hispanic population showed an increased risk of ALD prevalence, even with lower alcohol consumption. Additionally, Hispanic and Asian female patients had reduced access to liver transplantation compared to other enlisted patients., image
dc.fechaingreso.objetodigital2024-08-22
dc.fuente.origenWOS
dc.identifier.doi10.1111/liv.16023
dc.identifier.eissn1478-3231
dc.identifier.issn1478-3223
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85200258346
dc.identifier.urihttps://doi.org/10.1111/liv.16023
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87631
dc.identifier.wosidWOS:001282697600001
dc.information.autorucEscuela de Medicina; Ayares Campos, Gustavo Ignacio; 0000-0002-8651-2255; 1033904
dc.information.autorucEscuela de Medicina; Diaz Piga, Luis Antonio; 0000-0002-8540-4930; 179253
dc.information.autorucEscuela de Medicina; Fuentes Lopez, Eduardo; 0000-0002-0141-0226; 1013849
dc.information.autorucEscuela de Medicina; Idalsoaga Ferrer, Francisco Javier; S/I; 1017394
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherWILEY
dc.revistaLiver International
dc.rightsacceso abierto
dc.subjectCirrhosis
dc.subjectethnic disparities
dc.subjectoutcome prediction
dc.subjectEend-stage liver disease
dc.subjectAlcohol
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRacial and ethnic disparities in the natural history of alcohol-associated liver disease in the United States
dc.typepreprint
sipa.codpersvinculados1033904
sipa.codpersvinculados179253
sipa.codpersvinculados1013849
sipa.codpersvinculados1017394
sipa.trazabilidadWOS;2024-08-17
sipa.trazabilidadORCID
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