Regional brain atrophy is related to social cognition impairment in multiple sclerosis

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dc.catalogadorjwg
dc.contributor.authorLabbe Atenas, Tomás Pablo
dc.contributor.authorMontalba Zalaquett, Cristian Andrés
dc.contributor.authorZurita Soler, Mariana
dc.contributor.authorCiampi Diaz, Ethel Leslie
dc.contributor.authorAlbornoz Cruz, Juan Pablo
dc.contributor.authorVásquez Torres, Macarena
dc.contributor.authorUribe Arancibia, Sergio Andrés
dc.contributor.authorCrossley Karmelic, Nicolás Andrés
dc.contributor.authorCárcamo Rodríguez, Claudia Andrea
dc.date.accessioned2024-01-15T15:10:29Z
dc.date.available2024-01-15T15:10:29Z
dc.date.issued2021
dc.description.abstractBackground: Multiple sclerosis exhibits specific neuropathological phenomena driving to both global and regional brain atrophy. At the clinical level, the disease is related to functional decline in cognitive domains as the working memory, processing speed, and verbal fluency. However, the compromise of social-cognitive abilities has concentrated some interest in recent years despite the available evidence suggesting the risk of disorganization in social life. Recent studies have used the MiniSEA test to assess the compromise of social cognition and have found relevant relationships with memory and executive functions, as well as with the level of global and regional brain atrophy. Objective: The present article aimed to identify structural changes related to socio-cognitive performance in a sample of patients with relapsing-remitting multiple sclerosis. Methods: 68 relapsing-remitting multiple sclerosis Chilean patients and 50 healthy control subjects underwent MRI scans and neuropsychological evaluation including social-cognition tasks. Total brain, white matter, and gray matter volumes were estimated. Also, voxel-based morphometry was applied to evaluate regional structural changes. Results: Patients exhibited lower scores in all neuropsychological tests. Social cognition exhibited a significant decrease in this group mostly related to the declining social perception. Normalized brain volume and white matter volume were significantly decreased when compared to healthy subjects. The regional brain atrophy analysis showed that changes in the insular cortex and medial frontal cortices are significantly related to the variability of social-cognitive performance among patients. Conclusions: In the present study, social cognition was only correlated with the deterioration of verbal fluency, despite the fact that previous studies have reported its link with memory and executive functions. The identification of specific structural correlates supports the comprehension of this phenomenon as an independent source of cognitive disability in these patients.
dc.description.funderCONICYT (Comision Nacional de Ciencia y Tecnologia)
dc.description.funderCONICYT-PIA, CONICYT
dc.description.funderMillennium Science Initiative of the Ministry of Economy, Development and Tourism, grant Nucleus for Cardiovascular Magnetic Resonance
dc.description.funderCONICYT, FONDECYT Regular
dc.fechaingreso.objetodigital2024-01-15
dc.format.extent10
dc.fuente.origenWOS
dc.identifier.doi10.1590/0004-282X-ANP-2020-0162
dc.identifier.eissn1678-4227
dc.identifier.issn0004-282X
dc.identifier.pubmedidMEDLINE:34550187
dc.identifier.urihttps://doi.org/10.1590/0004-282X-ANP-2020-0162
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80458
dc.identifier.wosidWOS:000706741500003
dc.information.autorucEscuela de Medicina; Labbe Atenas Tomas Pablo; ; 249929
dc.information.autorucEscuela de Medicina; Montalba Zalaquett Cristian Andres; ; 1077325
dc.information.autorucEscuela de Ingeniería; Zurita Soler Mariana; ; 204137
dc.information.autorucEscuela de Medicina; Ciampi Diaz Ethel Leslie; 0000-0002-7330-5433; 132794
dc.information.autorucEscuela de Medicina; Albornoz Cruz Juan Pablo; ; 185025
dc.information.autorucEscuela de Medicina; Vasquez Torres Macarena; ; 1013048
dc.information.autorucEscuela de Medicina; Uribe Arancibia Sergio Andres; ; 16572
dc.information.autorucEscuela de Medicina; Crossley Karmelic Nicolas Andres; 0000-0002-3060-656X; 11224
dc.information.autorucEscuela de Medicina; Carcamo Rodriguez Claudia Andrea; 0000-0002-9430-216X; 562
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final675
dc.pagina.inicio666
dc.publisherASSOC ARQUIVOS NEURO- PSIQUIATRIA
dc.revistaARQUIVOS DE NEURO-PSIQUIATRIA
dc.rightsacceso abierto
dc.subjectMultiple Sclerosis
dc.subjectSocial Cognition
dc.subjectTheory of Mind
dc.subjectSocial Perception
dc.subjectBrain Atrophy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRegional brain atrophy is related to social cognition impairment in multiple sclerosis
dc.title.alternativeLa atrofia cerebral regional se relaciona con el deterioro de la cognición social en sclerosis múltiple
dc.typeartículo
dc.volumen79
sipa.codpersvinculados249929
sipa.codpersvinculados1077325
sipa.codpersvinculados204137
sipa.codpersvinculados132794
sipa.codpersvinculados185025
sipa.codpersvinculados1013048
sipa.codpersvinculados16572
sipa.codpersvinculados11224
sipa.codpersvinculados562
sipa.trazabilidadWOS;18-03-2022
sipa.trazabilidadORCID;2024-01-08
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