Equilibrative nucleoside transporters in fetal endothelial dysfunction in diabetes mellitus and hyperglycaemia

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dc.catalogadorpau
dc.contributor.authorWestermeier Lafuente, Francisco David
dc.contributor.authorPuebla Aracena, Carlos Alberto
dc.contributor.authorVega Pizarro, José Luis Eduardo
dc.contributor.authorFarías Jofré, Marcelo Enrique
dc.contributor.authorEscudero Orozco, Carlos Alonso
dc.contributor.authorCasanello Toledo, Paola Cecilia
dc.contributor.authorSobrevía Luarte, Luis Alberto
dc.date.accessioned2023-07-21T17:46:05Z
dc.date.available2023-07-21T17:46:05Z
dc.date.issued2009
dc.description.abstractDiabetes mellitus types 1 and 2, and gestational diabetes are characterized by abnormal D-glucose metabolism and hyperglycaemia, and induce foetal endothelial dysfunction with implications in adult life increasing the risk of vascular diseases. Synthesis of nitric oxide (NO) and uptake of L-arginine (i.e. the L-arginine/NO signalling pathway) and adenosine (a vasoactive endogenous nucleoside) by the umbilical vein endothelium is altered in pathological pregnancies, including pregnancies with pre-established diabetes mellitus or in gestational diabetes. The mechanisms underlying these alterations include differential expression of equilibrative nucleoside transporters (ENTs), amino acid transporters and NO synthases (NOS). Modulation of ENTs and NOS expression and activity in endothelium involves several signalling molecules, including protein kinase C, mitogen-activated protein kinases p42 and p44, calcium and phosphatidyl inositol 3 kinase. Elevated extracellular D-glucose and diabetes alters human endothelial function. However, information regarding modulation the transport capacity as well as expression of ENTs is limited. This review focuses on the effect of diabetes mellitus and gestational diabetes, and hyperglycaemia on the reported mechanisms described for transcriptional and posttranscriptional regulation of ENTs, and the potential consequences for foetal endothelial function in these pathologies. Recent available information regarding functional consequences of an abnormal environment on the functionality of the endothelium from microvasculature of the human placenta is mentioned. The available information is scarce, but it could contribute to a better understanding of the cell and molecular basis of the altered vascular endothelial function in this pathological conditions, emphasizing the key role of this type of epithelium in fetal-placental function and the normal foetal development and growth.
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.2174/157016109789043900
dc.identifier.issn1570-1611
dc.identifier.urihttp://dx.doi.org/10.2174/157016109789043900
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74230
dc.information.autorucFacultad de Ciencias Biológicas; Westermeier Lafuente, Francisco David; 0000-0002-4476-4198; 181374
dc.information.autorucFacultad de Ciencias Biológicas; Puebla Aracena, Carlos Alberto; 0000-0001-6648-2135; 124965
dc.information.autorucFacultad de Ciencias Biológicas; Vega Pizarro, José Luis Eduardo; 0000-0001-9333-8729; 165832
dc.information.autorucEscuela de medicina; Farías Jofré, Marcelo Enrique; S/I; 12286
dc.information.autorucEscuela de medicina; Escudero Orozco, Carlos Alonso; S/I; 158196
dc.information.autorucEscuela de medicina; Casanello Toledo, Paola Cecilia; 0000-0002-2355-1476; 146772
dc.information.autorucFacultad de Ciencias Biológicas; Casanello Toledo, Paola Cecilia; 0000-0002-2355-1476; 146772
dc.information.autorucEscuela de medicina; Sobrevía Luarte, Luis Alberto; 0000-0001-5802-2243; 1002656
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final449
dc.pagina.inicio435
dc.revistaCurrent Vascular Pharmacologyes_ES
dc.rightsacceso restringido
dc.subjectDiabetes
dc.subjectGestational diabetes
dc.subjectNucleoside
dc.subjectTransport
dc.subjectHuman
dc.subjectEndothelium
dc.titleEquilibrative nucleoside transporters in fetal endothelial dysfunction in diabetes mellitus and hyperglycaemiaes_ES
dc.typeartículo
dc.volumen7
sipa.codpersvinculados181374
sipa.codpersvinculados124965
sipa.codpersvinculados165832
sipa.codpersvinculados12286
sipa.codpersvinculados158196
sipa.codpersvinculados146772
sipa.codpersvinculados1002656
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