Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives

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dc.article.number132
dc.catalogadorpau
dc.contributor.authorOsorio, Julio C.
dc.contributor.authorBlanco, Rancés
dc.contributor.authorCorvalan, Alejandro H.
dc.contributor.authorMuñoz, Juan P.
dc.contributor.authorCalaf, Gloria M.
dc.contributor.authorAguayo, Francisco
dc.date.accessioned2024-06-08T14:48:34Z
dc.date.available2024-06-08T14:48:34Z
dc.date.issued2022
dc.description.abstract© 2022 by the authors. Licensee MDPI, Basel, Switzerland.Lung cancer (LC) is the leading cause of cancer death worldwide. Tobacco smoke is the most frequent risk factor etiologically associated with LC, although exposures to other environmental factors such as arsenic, radon or asbestos are also involved. Additionally, the involvement of some viral infections such as high-risk human papillomaviruses (HR-HPVs), Merkel cell polyomavirus (MCPyV), Jaagsiekte Sheep Retrovirus (JSRV), John Cunningham Virus (JCV), and Epstein– Barr virus (EBV) has been suggested in LC, though an etiological relationship has not yet been established. EBV is a ubiquitous gamma herpesvirus causing persistent infections and some lymphoid and epithelial tumors. Since EBV is heterogeneously detected in LCs from different parts of the world, in this review we address the epidemiological and experimental evidence of a potential role of EBV. Considering this evidence, we propose mechanisms potentially involved in EBV-associated lung carcinogenesis. Additional studies are warranted to dissect the role of EBV in this very frequent malignancy.
dc.description.funderANID-FONDECYT
dc.description.funderCONICYT-FONDAP
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-06-08
dc.fuente.origenScopus
dc.identifier.doi10.3390/pathogens11020132
dc.identifier.eissn2076-0817
dc.identifier.issn2076-0817
dc.identifier.scopusidSCOPUS_ID:85123237678
dc.identifier.urihttps://www.mdpi.com/2076-0817/11/2/132/pdf
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86635
dc.information.autorucEscuela de Medicina; Corvalan, Alejandro H.; 0000-0001-5492-3853; 63885
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherMDPI
dc.revistaPathogens
dc.rightsacceso abierto
dc.rightsacceso abierto
dc.subjectCancer
dc.subjectEpstein–Barr virus
dc.subjectLung
dc.titleEpstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives
dc.typereseña
dc.volumen11
sipa.codpersvinculados63885
sipa.trazabilidadSCOPUS;21-03-2022
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