Lysosome motility and distribution: relevance in health and disease

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dc.catalogadoryvc
dc.contributor.authorOyarzún, Juan Esteban
dc.contributor.authorLagos, Jonathan
dc.contributor.authorVázquez, Mary Carmen
dc.contributor.authorValls, Cristian
dc.contributor.authorFuente Millán, Catalina Andrea de la
dc.contributor.authorYuseff Sepúlveda, María Isabel
dc.contributor.authorÁlvarez, Alejandra R.
dc.contributor.authorZanlungo Matsuhiro, Silvana
dc.date.accessioned2024-06-06T19:19:44Z
dc.date.available2024-06-06T19:19:44Z
dc.date.issued2019
dc.description.abstractLysosomes are dynamic organelles, which can fuse with a variety of targets and undergo constant regeneration. They can move along microtubules in a retrograde and anterograde fashion by using motor proteins, kinesin and dynein, being main players in extracellular secretion, intracellular components degradation and recycling. Moreover, lysosomes interact with other intracellular organelles to regulate their turnover, such as ER, mitochondria and peroxisomes. The correct localization of lysosomes is relevant in several physiological processes, including appropriate antigen presentation, neurotransmission and receptors modulation in neuronal synapsis, whereas hepatic lysosomes and autophagy are master regulators of nutrient homeostasis. Alterations in lysosome function due to mutation of genes encoding lysosomal proteins, soluble hydrolases as well as membrane proteins, lead to lysosomal storage diseases (LSDs). Lysosomes containing undegraded substrates are finally stacked and therefore miss positioned inside the cell, leading to lysosomal dysfunction, which impacts a wide range of cellular functions.
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.bbadis.2019.03.009
dc.identifier.urihttps://doi.org/10.1016/j.bbadis.2019.03.009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86571
dc.information.autorucFacultad de Ciencias Biológicas;Fuente Millán, Catalina Andrea de la;215452
dc.information.autorucFacultad de Ciencias Biológicas;Yuseff Sepúlveda, María Isabel;0000-0001-8172-3785;229802
dc.information.autorucEscuela de Medicina;Zanlungo Matsuhiro, Silvana;0000-0001-8383-9829;72650
dc.language.isoen
dc.nota.accesocontenido parcial
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleLysosome motility and distribution: relevance in health and disease
dc.typeartículo
sipa.codpersvinculados72650
sipa.trazabilidadORCID;2024-06-03
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