Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone

Simple item page
dc.contributor.authorValderrama, Jaime A.
dc.contributor.authorEspinoza, Omar
dc.contributor.authorRodriguez, Jaime
dc.contributor.authorTheoduloz, Cristina
dc.date.accessioned2024-01-10T12:43:17Z
dc.date.available2024-01-10T12:43:17Z
dc.date.issued2009
dc.description.abstractThe synthesis of kigelinone thiophene analogs and related naphtho[2,3-b] thiophene-4,9-quinones from 2-substituted 4,7-dimethoxybenzo[b]thiophenes via an oxidative deprotection, Diels-Alder, and oxidative aromatization reaction sequence is reported. The 2-substituted naphtho[2,3-b] thiophene-4,9-quinones display significant antitumor activity in the range IC50 1.1-47 mu M on a panel of four distinct human cancer cell lines.
dc.description.funderFondo Nacional de Ciencia y Tecnologia
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.2174/157017809788490006
dc.identifier.eissn1875-6255
dc.identifier.issn1570-1786
dc.identifier.urihttps://doi.org/10.2174/157017809788490006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77582
dc.identifier.wosidWOS:000267046600003
dc.information.autorucQuímica;Espinoza O;S/I;8018
dc.information.autorucQuímica;Valderrama JA ;S/I;98772
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final281
dc.pagina.inicio278
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.revistaLETTERS IN ORGANIC CHEMISTRY
dc.rightsacceso restringido
dc.subjectQuinones
dc.subjectBenzo[b]thiophenes
dc.subjectOxidative deprotection
dc.subjectDiels-Alder reaction
dc.subjectRegioisomers
dc.subjectCitotoxicity
dc.subjectLEISHMANICIDAL ACTIVITY
dc.subjectANTIPROTOZOAL ACTIVITY
dc.subjectTABEBUIA-AVELLANEDAE
dc.subjectQUINONES
dc.subjectCYTOTOXICITY
dc.subjectFURANONAPHTHOQUINONES
dc.subjectHYDROQUINONES
dc.subjectRING
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone
dc.typeartículo
dc.volumen6
sipa.codpersvinculados8018
sipa.codpersvinculados98772
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-05-23. Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone.pdf
Size:
2.27 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas