Long-lasting neutralizing antibody responses in SARS-CoV-2 seropositive individuals are robustly boosted by immunization with the CoronaVac and BNT162b2 vaccines

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dc.catalogadoraba
dc.contributor.authorMuena, Nicolás A.
dc.contributor.authorGarcía Salum, Tamara Cristal
dc.contributor.authorPardo Roa, Catalina
dc.contributor.authorSerrano García, Eileen Francisca
dc.contributor.authorLevicán Asenjo, Jorge Enrique
dc.contributor.authorAvendaño, María José
dc.contributor.authorAlmonacid Cárdenas, Leonardo Iván
dc.contributor.authorValenzuela Galaz, Gonzalo Hernán
dc.contributor.authorPoblete Cárdenas, Estefany Aracely
dc.contributor.authorStrohmeier, Shirin
dc.contributor.authorSalinas Ortíz, Erick David
dc.contributor.authorHaslwanter, Denise
dc.contributor.authorDieterle, Maria Eugenia
dc.contributor.authorJangra, Rohit K.
dc.contributor.authorChandran, Kartik
dc.contributor.authorGonzález, Claudia
dc.contributor.authorRiquelme Pérez, Arnoldo Javier
dc.contributor.authorKrammer, Florian
dc.contributor.authorTischler, Nicole D.
dc.contributor.authorMedina, Rafael
dc.date.accessioned2024-06-10T21:25:29Z
dc.date.available2024-06-10T21:25:29Z
dc.date.issued2021
dc.description.abstractThe durability of circulating neutralizing antibody (nAb) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their boosting by vaccination remains to be defined. We show that outpatient and hospitalized SARS-CoV-2 seropositive individuals mount a robust neutralizing antibody (nAb) response that peaks at days 23 and 27 post-symptom onset, respectively. Although nAb titers remained higher in hospitalized patients, both study groups showed long-lasting nAb responses that can persist for up to 12 months after natural infection. These nAb responses in previously seropositive individuals can be significantly boosted through immunization with two doses of the CoronaVac (Sinovac) or one dose of the BNT162b2 (BioNTech/Pfizer) vaccines, suggesting a substantial induction of B cell memory responses. Noteworthy, three obese previously seropositive individuals failed to mount a booster response upon vaccination, warranting further studies in this population. Immunization of naïve individuals with two doses of the CoronaVac vaccine or one dose of the BNT162b2 vaccine elicited similar levels of nAbs compared to seropositive individuals 4.2 to 13.3 months post-infection with SARS-CoV-2. Thus, this preliminary evidence suggests that both, seropositive and naïve individuals, require two doses of CoronaVac to ensure the induction of robust nAb titers.
dc.fechaingreso.objetodigital2024-06-11|
dc.format.extent25 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1101/2021.05.17.21257197
dc.identifier.urihttps://doi.org/10.1101/2021.05.17.21257197
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86692
dc.information.autorucEscuela de Medicina; García Salum, Tamara Cristal; S/I; 121228
dc.information.autorucFacultad de Ciencias Biológicas; Pardo Roa, Catalina; 0000-0002-5409-225X; 225251
dc.information.autorucFacultad de Ciencias Biológicas; Serrano García, Eileen Francisca; S/I; 1086419
dc.information.autorucS/I; Levicán Asenjo, Jorge Enrique; S/I; 114062
dc.information.autorucEscuela de Medicina; Valenzuela Galaz, Gonzalo Hernán; S/I; 213128
dc.information.autorucEscuela de Medicina; Poblete Cárdenas, Estefany Aracely; S/I; 1186898
dc.information.autorucEscuela de Medicina; Salinas Ortíz, Erick David; S/I; 1101975
dc.information.autorucEscuela de Medicina; Riquelme Pérez, Arnoldo Javier; 0000-0002-8259-8960; 3538
dc.information.autorucEscuela de Medicina; Medina, Rafael; 0000-0002-5013-6884; 1000649
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final25
dc.pagina.inicio1
dc.revistamedRxiv
dc.rightsacceso abierto
dc.rights.licenseATTRIBUTION-NONCOMMERCIAL-NODERIVS 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCOVID-19
dc.subjectSerological response
dc.subjectNeutralizing antibody persistence
dc.subjectSARS-CoV 2 vaccines
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleLong-lasting neutralizing antibody responses in SARS-CoV-2 seropositive individuals are robustly boosted by immunization with the CoronaVac and BNT162b2 vaccines
dc.typepreprint
sipa.codpersvinculados121228
sipa.codpersvinculados225251
sipa.codpersvinculados1086419
sipa.codpersvinculados114062
sipa.codpersvinculados213128
sipa.codpersvinculados1186898
sipa.codpersvinculados1101975
sipa.codpersvinculados3538
sipa.codpersvinculados1000649
sipa.trazabilidadORCID;2024-06-03
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