Oral propranolol for treating infantile hemangiomas: a case series of 57 patients

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dc.contributor.authorZegpi Trueba, María Soledad
dc.contributor.authorAbarzúa, Alvaro
dc.contributor.authorSilva-Valenzuela, S.
dc.contributor.authorNavarrete-Dechent, C.
dc.contributor.authorUribe-Gonzalez, P.
dc.contributor.authorNicklas-Diaz, C.
dc.date.accessioned2020-01-12T03:51:27Z
dc.date.available2020-01-12T03:51:27Z
dc.date.issued2012
dc.description.abstractAbstract Introduction and objectives Infantile hemangiomas (IH) are a frequent vascular tumor. In recent years, propranolol has emerged as an alternative in the treatment of IH. The objective of the present study was to evaluate the effectiveness of propranolol for the treatment of IH. Materials and methods Patients with IH requiring treatment were included. Cardiologic evaluation was made to every patient and electrocardiogram (ECG) and echocardiogram were done. Oral propranolol was started in an ambulatory way at a dose of 2 mg/kg daily divided in two doses. At ten days all the patients were evaluated with a 24-h rhythm holter. Evaluation of effectiveness: In clinical controls and by images IH were formally analyzed, without blindness. Response was categorized as complete response (CR), partial response (PR) and no response (NR). Adverse events: Adverse events were registered in a special category of the formulary. Results 57 patients were included. Mean age was 9.7 months. There were 80.8% females. Mean duration of treatment was 7.3 months (1–24 months). Efficacy: 50.6% had CR, 49.3% had PR. There were a 7% of adverse events. No differences in response rate exist according to age or location. No rhythm holter was altered at ten-day control. Conclusion Our study highlights the possibility of starting propranolol in an ambulatory way, establishes a dose of 2 mg/kg/day and confirms the security profile of the drug. We consider propranolol as a first line treatment for IH.
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.1016/j.ad.2012.03.010
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27409
dc.issue.numeroNo. 8
dc.language.isoen
dc.revistaActas Dermo-Sifiliográficases_ES
dc.rightsacceso restringido
dc.subjectAdministration, Orales_ES
dc.subjectFemalees_ES
dc.subjectHemangioma, Capillary/*drug therapyes_ES
dc.subjectHumanses_ES
dc.subjectInfantes_ES
dc.subjectMalees_ES
dc.subjectPropranolol/*administration & dosagees_ES
dc.subjectProspective Studieses_ES
dc.subjectSkin Neoplasms/*drug therapyes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleOral propranolol for treating infantile hemangiomas: a case series of 57 patientses_ES
dc.typeartículo
dc.volumenVol. 103
sipa.codpersvinculados85465
sipa.codpersvinculados100119
sipa.codpersvinculados156251
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