Assessment of Mycotoxin Exposure in a Rural County of Chile by Urinary Biomarker Determination

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dc.catalogadoryvc
dc.contributor.authorFoerster, Claudia
dc.contributor.authorRíos-Gajardo, Gisela
dc.contributor.authorGómez, Patricia
dc.contributor.authorMuñoz, Katherine
dc.contributor.authorCortés Arancibia, Sandra Isabel
dc.contributor.authorMaldonado, Carlos
dc.contributor.authorFerreccio Readi, Fresia Catterina
dc.contributor.otherCEDEUS (Chile)
dc.date.accessioned2024-01-19T14:06:45Z
dc.date.available2024-01-19T14:06:45Z
dc.date.issued2021
dc.description.abstractAflatoxin B1 (AFB1), ochratoxin A (OTA), zearalenone (ZEN), and deoxynivalenol (DON) are frequent mycotoxins that may cause carcinogenic, mutagenic, estrogenic, or gastrointestinal effects. The aim of this study was to assess the exposure to and risk from AFB1, OTA, ZEN, and DON in 172 participants of the Maule Cohort (MAUCO) by a biomarker analysis in urine and to associate their exposure with food consumption and occupation. Mycotoxins in the first morning urine were analyzed by solid-phase extraction and quantified by Ultra-High-Performance Liquid Chromatography with a mass–mass detector. Participants’ information regarding food consumption, occupation, and other characteristics was obtained from a baseline and 2-year follow-up survey of the cohort. The prevalence and mean levels of mycotoxins in the urine were as follows: DON 63%, 60.7 (±78.7) ng/mL; AFB1 8%, 0.3 (±0.3) ng/mL; α-zearalenol (α-ZEL) 4.1%, 41.8 (±115) ng/mL; β ZEL 3.5%, 17.4 (±16.1) ng/mL; AFM1 2%, 1.8 (±1.0) ng/mL; OTA 0.6% (1/172), 1.3 ng/mL; and ZEN 0.6%, 1.1 ng/mL. These results were translated into exposures of DON, ZEN, and aflatoxins of public health concern. Participants who consumed coffee and pepper the day before had a significantly greater presence of DON (OR: 2.3, CI95 1.17–4.96) and total ZEL (OR: 14.7, CI95 3.1–81.0), respectively, in their urine. Additionally, we observed associations between the habitual consumption of beer and DON (OR: 2.89, CI95 1.39– .42). Regarding the levels of mycotoxins and the amount of food consumed, we found correlations between DON and nuts (p = 0.003), total ZEL and cereals (p = 0.01), and aflatoxins with capsicum powder (p = 0.03) and walnuts (p = 0.03). Occupation did not show an association with the presence of mycotoxins in urine.
dc.fechaingreso.objetodigital2024-02-28
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3390/toxins13070439
dc.identifier.urihttps://doi.org/10.3390/toxins13070439
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80634
dc.information.autorucEscuela de medicina ; Cortés Arancibia, Sandra Isabel ; 0000-0003-3293-1419 ; 1005970
dc.information.autorucEscuela de medicina ; Ferreccio Readi, Fresia Catterina ; 0000-0001-6331-5534 ; 99684
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.revistaToxins
dc.rightsacceso abierto
dc.subjectAflatoxin
dc.subjectOchratoxin A
dc.subjectDeoxynivalenol
dc.subjectZearalenone
dc.subjectUrine biomonitoring
dc.subjectFood
dc.subjectOccupation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAssessment of Mycotoxin Exposure in a Rural County of Chile by Urinary Biomarker Determination
dc.typeartículo
dc.volumen13
sipa.codpersvinculados1005970
sipa.codpersvinculados99684
sipa.trazabilidadORCID;2024-01-08
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