Dynamics of Prolyl Hydroxylases Levels During Disease Progression in Experimental Colitis

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dc.contributor.authorBakshi, Hamid A.
dc.contributor.authorMishra, Vijay
dc.contributor.authorSatija, Saurabh
dc.contributor.authorMehta, Meenu
dc.contributor.authorHakkim, Faruk L.
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorDua, Kamal
dc.contributor.authorChellappan, Dinesh K.
dc.contributor.authorCharbe, Nitin B.
dc.contributor.authorShrivastava, Garima
dc.contributor.authorRajeshkumar, S.
dc.contributor.authorAljabali, Alaa A.
dc.contributor.authorAl-Trad, Bahaa
dc.contributor.authorPabreja, Kavita
dc.contributor.authorTambuwala, Murtaza M.
dc.date.accessioned2025-01-23T21:09:31Z
dc.date.available2025-01-23T21:09:31Z
dc.date.issued2019
dc.description.abstractHypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitors are shown to be protective in several models of inflammatory bowel disease (IBD). However, these non-selective inhibitors are known to inhibit all the three isoforms of PHD, i.e. PHD-1, PHD-2 and PHD-3. In the present report, we investigated the associated changes in levels of PHDs during the development and recovery of chemically induced colitis in mice. The results indicated that in the experimental model of murine colitis, levels of both, PHD-1 and PHD-2 were found to be increased with the progression of the disease; however, the level of PHD-3 remained the same in group of healthy controls and mice with colitis. Thus, the findings advocated that inhibitors, which inhibited all three isoforms of PHD could not be ideal therapeutics for IBD since PHD-3 is required for normal gut function. Hence, this necessitates the development of new compounds capable of selectively inhibiting PHD-1 and PHD-2 for effective treatment of IBD.
dc.description.funderUlster University
dc.fuente.origenWOS
dc.identifier.doi10.1007/s10753-019-01065-3
dc.identifier.eissn1573-2576
dc.identifier.issn0360-3997
dc.identifier.urihttps://doi.org/10.1007/s10753-019-01065-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100818
dc.identifier.wosidWOS:000496593400011
dc.issue.numero6
dc.language.isoen
dc.pagina.final2036
dc.pagina.inicio2032
dc.revistaInflammation
dc.rightsacceso restringido
dc.subjectprolyl hydroxylases
dc.subjectinflammatory bowel disease
dc.subjectcolitis
dc.subjectdisease activity index
dc.titleDynamics of Prolyl Hydroxylases Levels During Disease Progression in Experimental Colitis
dc.typeartículo
dc.volumen42
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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