Safety of long-acting β agonists for the treatment of asthma: Clearing the air

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dc.contributor.authorRodrigo, Gustavo Javier
dc.contributor.authorCastro Rodríguez, José Antonio
dc.date.accessioned2022-01-05T18:49:35Z
dc.date.available2022-01-05T18:49:35Z
dc.date.issued2012
dc.description.abstractConcerns about the safety of long-acting β2-agonist (LABA) therapy, has led to the appearance of multiple publications and recommendations. This review critically examines the available clinical evidence and safety requirements for LABA use. On the basis of nearly 20 systematic reviews and databases, the authors conclude that LABA monotherapy significantly increases the risk of asthma-related adverse effects. We also conclude that the use of LABAs concomitantly with inhaled corticosteroids (ICS) significantly reduces asthma hospitalisations and is not associated with life-threatening events and asthma-related deaths, especially when concurrent use of LABAs and ICS can be reasonably assured (use of a single inhaler device). An appropriate clinical study would require an extremely large sample, making it impractical. Finally, some of the new US Food and Drug Administration (FDA) recommendations have caused confusion and do not appear to be fully evidence based. Although limited by low statistical power, the evidence supports the use of LABAs plus ICS in a single inhaler device (to increase adherence and reduce the potential use of LABA monotherapy) for all patients (not only children) with moderate to severe asthma.
dc.fuente.origenORCID
dc.identifier.doi10.1136/thx.2010.155648
dc.identifier.issn0040-6376
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84858796735&partnerID=MN8TOARS
dc.identifier.urihttps://www.doi.org/10.1136/thx.2010.155648
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/63113
dc.information.autorucEscuela de medicina ; Castro Rodríguez, José Antonio ; 0000-0002-0708-4281 ; 113247
dc.issue.numeroNo. 4
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final349
dc.pagina.inicio342
dc.provenancengjara 2022-01-05 15:49:35
dc.relation.isformatofThorax, vol. 67, no. 4 (abr. 2012), pp. 342-349.
dc.revistaThorax
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherMedicina y salud
dc.titleSafety of long-acting β agonists for the treatment of asthma: Clearing the air
dc.typeartículo
dc.volumenVol. 67
sipa.codpersvinculados113247
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