A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds

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dc.catalogadorjwg
dc.contributor.authorObaid, Miguel Luis
dc.contributor.authorCamacho, Juan Pablo
dc.contributor.authorBrenet, Marianne
dc.contributor.authorCorrales Orovio, Rocio
dc.contributor.authorCarvajal Diaz, Felipe Alonso
dc.contributor.authorMartorell, Ximena
dc.contributor.authorWerner, Consuelo
dc.contributor.authorSimon, Valeska
dc.contributor.authorVaras, Juan
dc.contributor.authorCalderon, Wilfredo
dc.contributor.authorGuzman, Christian Dani
dc.contributor.authorBono, Maria Rosa
dc.contributor.authorSan Martin, Sebastián
dc.contributor.authorEblen Zajjur, Antonio Alejandro
dc.contributor.authorEgaña Erazo, José Tomás
dc.date.accessioned2024-01-29T19:44:23Z
dc.date.available2024-01-29T19:44:23Z
dc.date.issued2021
dc.description.abstractInsufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence of a vascular supply. This approach has been demonstrated to be successful in several in vitro and in vivo models; however, no data is available about their safety in human patients. Here, an early phase-1 clinical trial ( identifier: NCT03960164, ) is presented to evaluate the safety and feasibility of implanting photosynthetic scaffolds for dermal regeneration in eight patients with full-thickness skin wounds. Overall, this trial shows that the presence of the photosynthetic microalgae Chlamydomonas reinhardtii in the implanted scaffolds did not trigger any deleterious local or systemic immune responses in a 90 days follow-up, allowing full tissue regeneration in humans. The results presented here represent the first attempt to treat patients with photosynthetic cells, supporting the translation of photosynthetic therapies into clinics.
dc.description.funderCORFO Portafolio I+D grant
dc.description.funderFONDECYT
dc.description.funderFONDEQUIP/EQM
dc.fechaingreso.objetodigital2024-04-19
dc.format.extent14 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3389/fmed.2021.772324
dc.identifier.eissn2296-858X
dc.identifier.pubmedidMEDLINE:34917636
dc.identifier.urihttps://doi.org/10.3389/fmed.2021.772324
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81046
dc.identifier.wosidWOS:000731887500001
dc.information.autorucFacultad de Ciencias Biológicas; Carvajal Diaz Felipe Alonso; ; 171996
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Egaña Erazo Jose Tomas; 0000-0003-2624-6992; 1018715
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Eblen Zajjur Antonio Alejandro; ; 1051050
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherFRONTIERS MEDIA SA
dc.revistaFrontiers in Medicine
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods06 Clean Water and Sanitation
dc.subject.odspa06 Agua limpia y saneamiento
dc.titleA First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds
dc.typeartículo
dc.volumen8
sipa.codpersvinculados171996
sipa.codpersvinculados1018715
sipa.codpersvinculados1051050
sipa.trazabilidadORCID;2024-01-15
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