Prevalence, clinical profile, and cardiovascular outcomes of atrial fibrillation patients with atherothrombosis

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dc.contributor.authorGoto, Shinya
dc.contributor.authorHatt, Deepak L.
dc.contributor.authorRoether, Joachim
dc.contributor.authorAlberts, Mark
dc.contributor.authorHill, Michael D.
dc.contributor.authorIkeda, Yasuo
dc.contributor.authorUchiyama, Shinichiro
dc.contributor.authorD'Agostino, Ralph
dc.contributor.authorOhman, E. Magnus
dc.contributor.authorLiau, Chiau Suong
dc.contributor.authorHirsch, Alan T.
dc.contributor.authorMas, Jean Louis
dc.contributor.authorWilson, Peter W. F.
dc.contributor.authorCorbalan, Ramon
dc.contributor.authorAichner, Franz
dc.contributor.authorSteg, P. Gabriel
dc.contributor.authorREACH Registry Invest
dc.date.accessioned2024-01-10T12:07:40Z
dc.date.available2024-01-10T12:07:40Z
dc.date.issued2008
dc.description.abstractBackground Atrial fibrillation (AF) is a major risk factor (RF) for ischemic stroke. Its prevalence and prognostic impact in patients with atherothrombosis are unclear.
dc.description.abstractMethods Risk factors, drug usage, and 1-year cardiovascular (CV) outcomes (CV death, myocardial infarction [MI], and stroke) were compared in AF and non-AF patients from the REduction of Atherothrombosis for Continued Health (REACH) Registry, an international, prospective cohort of 68,236 stable outpatients with established otherothrombosis or >= 3 atherothrombotic RFs.
dc.description.abstractResult Atrial fibrillation and 1-year follow-up data are available for 63,589 patients. The prevalence of AF was, 12.5%, 13.7%, 11.5%, and 6.2% among coronary artery disease, CV disease, peripheral artery disease, and RF-only patients, respectively. Of the 6,814 patients with AF, 6.7% experienced CV death, nonfatal MI, or nonfatal stroke within a year. The annual incidence of nonfatal stroke (2.4% vs 1.6%, P < .0001) and unstable angina (6.0% vs 4.0%, P < .00001) was higher, and CV death was more than double (3.2% vs 1.4%, P < .0001), in AF versus non-AF patients. In these patients with or at high risk of atherothrombosis, most patients with AF received antiplatelet agents, but only 53.1% were treated with oral anticoagulants. Even with high CHADS(2) (congestive heart failure, hypertension, aging, diabetes mellitus, and stroke) scores, anticoagulant use did not exceed (59%). The rate of bleeding requiring hospitalization was higher in AF versus non-AF patients (1.5% vs 0.8%, P < .0001), possibly related to the more frequent use of anticoagulants (53.1% vs 7.1%).
dc.description.abstractConclusions Atrial fibrillation is common in patients with atherothrombosis, associated with more frequent fatal and nonfatal CV outcomes, and underuse of oral anticoagulants. (Am Heart J 2008; 156:855-63.)
dc.fechaingreso.objetodigital2024-03-19
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ahj.2008.06.029
dc.identifier.eissn1097-5330
dc.identifier.issn0002-8703
dc.identifier.pubmedidMEDLINE:19061698
dc.identifier.urihttps://doi.org/10.1016/j.ahj.2008.06.029
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76311
dc.identifier.wosidWOS:000260700100011
dc.information.autorucMedicina;Corbalán R;S/I;98700
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final863
dc.pagina.inicio855
dc.publisherMOSBY-ELSEVIER
dc.revistaAMERICAN HEART JOURNAL
dc.rightsacceso restringido
dc.subjectPERCUTANEOUS CORONARY INTERVENTION
dc.subjectRISK-FACTORS
dc.subjectSTROKE PREVENTION
dc.subjectCLASSIFICATION SCHEMES
dc.subjectANTIPLATELET THERAPY
dc.subjectPREDICTING STROKE
dc.subjectLIFETIME RISK
dc.subjectASPIRIN
dc.subjectCLOPIDOGREL
dc.subjectPOPULATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrevalence, clinical profile, and cardiovascular outcomes of atrial fibrillation patients with atherothrombosis
dc.typeartículo
dc.volumen156
sipa.codpersvinculados98700
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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