Adverse drug reactions (ADRs) in hospitalized pediatric patients. A prospective study

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dc.contributor.authorGonzalez Martin, G
dc.contributor.authorCaroca, CM
dc.contributor.authorParis, E
dc.date.accessioned2024-01-10T13:10:55Z
dc.date.available2024-01-10T13:10:55Z
dc.date.issued1998
dc.description.abstractThe aim of this study was to determine the frequency and the characteristics of ADRs in 219 hospitalized pediatric patients, using an intensive and prospective drug surveillance method. The frequency of ADRs in these patients was 13.7%. The systems most commonly affected were the gastrointestinal (32.5%), the central nervous (20.0%), and the metabolic systems (17.5%). Asparaginase, methotrexate, phenytoin, phenobarbital, erythromycin, and salbutamol were probably the drugs associated with the ADRs, According to causality, 54.2% of the ADRs were regarded as probable, and 32.2% as possible. The majority of the ADRs were moderate (51.2%), 27.9% were severe. The main treatment of the ADRs was the withdrawal of the suspected drugs. The length of the slay in the hospital and the total number of drugs given to the patients influenced significantly the frequency of ADRs. 93% of the ADRs were dose-dependent.
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.issn0946-1965
dc.identifier.pubmedidMEDLINE:9799056
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77960
dc.identifier.wosidWOS:000076373200004
dc.information.autorucQuímica;González G;S/I;98524
dc.issue.numero10
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final533
dc.pagina.inicio530
dc.publisherDUSTRI-VERLAG DR KARL FEISTLE
dc.revistaINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
dc.rightsregistro bibliográfico
dc.subjectpediatric patients
dc.subjectadverse drug reactions
dc.subjectdrug surveillance
dc.subjectPROGRAM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdverse drug reactions (ADRs) in hospitalized pediatric patients. A prospective study
dc.typeartículo
dc.volumen36
sipa.codpersvinculados98524
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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