Evaluation of the crossed cerebro-cerebellar activation to determine language lateralization in patients with brain tumors

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dc.contributor.authorMendez Orellana, Carolina
dc.contributor.authorArrano Carrasco, Leonardo
dc.contributor.authorCortes Rivera, Barbara
dc.contributor.authorSandoval Leon, Karina
dc.contributor.authorLorenzoni Santos, Jose
dc.contributor.authorVillanueva Garin, Pablo
dc.contributor.authorRojas Valdivia, Ricardo
dc.contributor.authorMendez Ortega, Teobaldo
dc.contributor.authorMonsalve Rosales, Jaime
dc.contributor.authorFlores Kruuse, Paulo
dc.contributor.authorCarmona Rammsy, Pablo
dc.contributor.authorRojas Pinto, David
dc.contributor.authorReyes Ponce, Alvaro
dc.contributor.authorMery Munoz, Francisco
dc.date.accessioned2024-01-10T14:23:04Z
dc.date.available2024-01-10T14:23:04Z
dc.date.issued2021
dc.description.abstractBackground: The crossed cerebro-cerebellar (CCC) activation facilitates the diagnosis of cortical language lateralization, but needs to be explored with language tasks suitable for patients with different age ranges, educational attainment and eventual presence of language deficits. Aim: To determine the effect of demographic variables in the performance of three language tasks in healthy volunteers and to determine the CCC activation of these tasks as a functional magnetic resonance imaging (fMRI) paradigm in brain tumor patients. Material and Methods: The behavioral performance (correct responses and reaction time) of three language tasks (verbal fluency, semantic and phonological decision tasks) was first examined in 76 healthy volunteers balanced by age and educational level. Later, these tasks were implemented as fMRI paradigms to explore CCC language activation of 20 patients with potential diagnosis of brain tumors. Results: The performance of the verbal fluency task was affected by age. The CCC language activation was reproducible with the semantic and phonological tasks. The combination of the tasks determined typical and atypical language lateralization in 60% and 40% of our patients, respectively. Conclusions: The verbal fluency task must be implemented with care as a clinical fMRI paradigm. Our results suggest that semantic and phonological tasks can be a good alternative for brain tumor patients with language deficits.
dc.fechaingreso.objetodigital2024-06-24
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:34751321
dc.identifier.urihttp://dx.doi.org/10.4067/s0034-98872021000500689
dc.identifier.wosidWOS:000727961100004
dc.information.autorucFacultad de Medicina; Mendez Orellana, Carolina Patricia; S/I; 1015155
dc.issue.numero5
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final697
dc.pagina.inicio689
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso abierto
dc.subjectBrain Neoplasms
dc.subjectCerebellum
dc.subjectFunctional Laterality
dc.subjectLanguage
dc.subjectMagnetic Resonance Imaging
dc.subjectRESTING-STATE FMRI
dc.subjectDOMINANCE
dc.subjectHEMISPHERE
dc.subjectEDUCATION
dc.subjectFLUENCY
dc.subjectGLIOMA
dc.subjectTASK
dc.subjectAGE
dc.titleEvaluation of the crossed cerebro-cerebellar activation to determine language lateralization in patients with brain tumors
dc.typeartículo
dc.volumen149
sipa.codpersvinculados1015155
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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